PTP gamma/PTPRG Antibody

Product Discontinued

PTP gamma/PTPRG Antibody Summary

• Immunogen: Synthetic peptide from human PTPRG.
• Specificity: Amino acids 765 to 782 of human PTPRG
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PTPRG
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:10-1:1000
  • Immunohistochemistry 10 ug/ml
  • Immunohistochemistry-Paraffin 10 ug/ml
• Application Notes: IHC: NBP1-02517 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 27539848).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Protein G purified

Alternate Names for PTP gamma/PTPRG Antibody

• EC 3.1.3.48
• H_RG317H01.1
• HPTPG
• protein tyrosine phosphatase, receptor type, G
• protein tyrosine phosphatase, receptor type, gamma polypeptide
• Protein-tyrosine phosphatase gamma
• PTP gamma
• PTPG
• PTPGprotein tyrosine phosphatase gamma
• PTPRG
• receptor type protein tyrosine phosphatase gamma
• receptor tyrosine phosphatase gamma
• receptor-type protein phosphatase gamma
• receptor-type tyrosine-protein phosphatase gamma
• RPTPG
• R-PTP-GAMMA

Background

PTP gamma, a R5 receptor protein tyrosine phosphatase, has been implicated as a potential tumor suppressor gene in kidney, lung, ovary and breast cancers. PTP gamma maps to a region of human chromosome 3, 3p21, that is frequently deleted in renal cell carcinoma and lung carcinoma. PTP gamma expression has been shown to be reduced in breast and lung cancer cell lines and the expression in breast cancer is regulated by 17 beta-estradiol (E2) and Zeranol. Four protein isoforms of PTP gamma have been documented in rats.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PTP gamma/PTPRG Antibody (NBP1-02517)(1)

Publication using NBP1-02517

• Nikolaienko RM, Hammel M, Dubreuil V et al. Structural Basis for Interactions Between Contactin Family Members and Protein Tyrosine Phosphatase Receptor Type G in Neural Tissues. J. Biol. Chem. 2016-08-18 [PMID: 27539848] (IF/IHC, Mouse)

Bioinformatics

• Gene Symbol: PTPRG
• Entrez:
  • 5793(Human)
• Uniprot:
  • P23470()