PSMC3IP Antibody

Product Discontinued

PSMC3IP Antibody Summary

• Immunogen: This antibody was developed against Recombinant Protein corresponding to amino acids: PEEKEQVYRERQKYCKEWRKRKRMATELSDAILEGYPKSKKQFFEEVGIETDEDYNVTLPD
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PSMC3IP
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1 - 4 ug/ml
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
  • Simple Western 1:20
  • Western Blot 0.04 - 0.4 ug/ml
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Reactivity Notes

Human reactivity reported in scientific literature (PMID: 25590583).

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for PSMC3IP Antibody

• DBD-interacting
• GT198 alternative
• GT198
• homologous-pairing protein 2 homolog
• HOP2
• HUMGT198A
• Nuclear receptor coactivator GT198
• Proteasome 26S ATPase subunit 3-interacting protein
• PSMC3 interacting protein
• Tat-binding protein 1-interacting protein
• TBP-1 interacting protein
• TBP-1-interacting protein
• TBPIPPSMC3-interacting protein

Background

PSMC3IP plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop f

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PSMC3IP Antibody (NBP1-92301)(4)

Publications using NBP1-92301

• Perdun Z. INVESTIGATING THE PROFILE OF ABERRANTLY EXPRESSED MEIOTIC GENES IN ALT POSITIVE AND NEGATIVE CANCER CELL LINES Thesis 2017-01-01 (WB, Human)
• Dilley RL, Verma P, Cho NW et al. Break-induced telomere synthesis underlies alternative telomere maintenance. Nature 2016-10-19 [PMID: 27760120] (ICC/IF, Human)
• Capdevila-Busquets E, Badiola N, Arroyo R et al. Breast Cancer Genes PSMC3IP and EPSTI1 Play a Role in Apoptosis Regulation. PLoS One 2015-01-01 [PMID: 25590583] (WB, Human)
• Cho NW, Dilley RL, Lampson MA, Greenberg RA. Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis. Cell. 2014-09-25 [PMID: 25259924]

Bioinformatics

• Gene Symbol: PSMC3IP