38 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Immunogen displays the following percentage of sequence identity for non-tested species: Bovine: (88%)
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
Peptide affinity purified
Alternate Names for SLC39A1 Antibody - BSA Free
solute carrier family 39 (zinc transporter), member 1
solute carrier family 39 (zinc transporter), member 3
ZIP1, also known as ZIRTL (zinc-iron regulated transporter-like), is the first mammalian member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP1 expression is markedly downregulated in a number of cancerous tissues and is thought to function as a tumor suppressor gene in prostate cancer. More recent studies have shown that overexpression of ZIP1 and concomitant increased levels of intracellular zinc in PC-3 cells cause a significant inhibition of NF-kappaB, leading to down-regulation of the antiapoptotic protein Bcl-2, Bcl-XL, and the apoptosis inhibitor XIAP, reducing the malignant potential of prostate cancer cells in vitro and in vivo.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for SLC39A1 Antibody (NBP1-76498). (Showing 1 - 1 of 1 FAQ).
I would like to measure Slc39a1 expression profile in my samples, rat brain tissue lysates. Do you think I can use this antibody?
The SLC39A1 antibody with catalog number NBP1-76498 is covered by the Novus Guarantee to detect SLC39A1 by Western blotting, ELISA and IHC in human and mouse samples. Unfortunately we do not yet have any testing data in rat samples. The immunogen used to generate this antibody was a 16 amino acid peptide near the amino terminus of human ZIP1. However I was unable to run an alignment between the human and rat proteins for you, since the rat sequence is not yet available on UniProt. If you can provide the rat sequence I will be happy to carry out the alignment for you to check the sequence homology between human and rat. Alternatively you may be interested in our Innovators Reward Program. This allows you to try our primary antibodies in an untested species or application, without the financial risk of failure. You simply complete an online review with an image, detailing the positive or negative results of your study, and in return you receive a discount voucher for 100% of the purchase price of the reviewed product. You can also submit reviews by emailing email@example.com.
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