PSMB10/MECL1 Antibody [mFluor Violet 610 SE]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: mFluor Violet 610 SE

PSMB10/MECL1 Antibody [mFluor Violet 610 SE] Summary

• Immunogen: E. coli-derived recombinant human PSMB10/MECL1
  Thr40-Glu273
  Accession # P40306
• Specificity: Detects human PSMB10/MECL1 in direct ELISAs and Western blots. In direct ELISAs, less than 6% cross-reactivity with recombinant human PSMB7 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: PSMB10
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for PSMB10/MECL1 Antibody [mFluor Violet 610 SE]

• beta2i
• FLJ00366
• LMP10
• LMP10Proteasome subunit beta-2i
• Low molecular mass protein 10
• Macropain subunit MECl-1
• MECL1
• MECl-1
• MECL1EC 3.4.25.1
• MGC1665
• Multicatalytic endopeptidase complex subunit MECl-1
• proteasome (prosome, macropain) subunit, beta type, 10
• proteasome catalytic subunit 2i
• Proteasome MECl-1
• proteasome subunit beta 7i
• proteasome subunit beta type-10
• Proteasome subunit beta-2i
• proteasome subunit MECL1
• PSMB10

Background

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PSMB10