Protein Kinase D2 [p Ser876] Antibody (24GB1655)

• Reactivity: Hu
• Applications: WB, Flow, ICC/IF
• Clone: 24GB1655
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated

Protein Kinase D2 [p Ser876] Antibody (24GB1655) Summary

• Immunogen: A synthesized peptide derived from human Phospho-Protein Kinase D2 (S876) (Uniprot: Q9BZL6)
• Modification: p Ser876
• Specificity: This antibody detects endogenous levels of PRKD2 only when phosphorylated at S876
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: PRKD2
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4), 50% glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for Protein Kinase D2 [p Ser876] Antibody (24GB1655)

• DKFZP586E0820
• EC 2.7.11
• EC 2.7.11.13
• nPKC-D2
• PKD2HSPC187
• PRKD2
• protein kinase D2
• serine/threonine-protein kinase D2

Background

Protein kinases constitute a large superfamily of enzymes with key regulatory functions in nearly all signal transmission processes of eukaryotic cells; PKD2 is a novel phorbol ester and growth factor-stimulated protein kinase (1). PKD2 is widely expressed in human and murine tissues and in cell lines such as HL60. In vivo, phorbol ester has been shown to autophosphorylate PKD2 in a synergistic fashion. Phosphorylation of Ser(876) of PKD2 correlated with the activation status of the kinase. The first zinc finger-like domain shares 88% identity to the corresponding domains in PKD/PKC-mu and PKC-nu (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PRKD2