PRL/PTP4A Antibody (334407) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: IHC
• Clone: 334407
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

PRL/PTP4A Antibody (334407) [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human PRL-3
  Ala2-Met173
  Accession # O75365
• Specificity: Detects human PRL-2 and human PRL-3 with equal affinities in direct ELISAs. In direct ELISAs, this antibody shows 10% cross-reactivity with recombinant human PRL-1.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PRL/PTP4A Antibody (334407) [Alexa Fluor® 647]

• HH72;PRL1;PRL-1;Protein tyrosine phosphatase type IVA 1;PTP(CAAX1);PTP4A1;PTPCAAX1
• PRL/PTP4A

Background

Phosphatase of Regenerating Liver (PRL), also known as PTP4A, dephosphorylates tyrosine residues on proteins. Three PRL variants, PRL-1 (PTP4A1), PRL-2 (PTP4A2), and PRL-3 (PTP4A3) have been cloned and are 75% to 86% homologous. Prenylation at the C-terminal end targets PRL family members to membrane compartments in the cell, especially to early endosomes and the plasma membrane. PRL levels may correlate with cell migration rates and tumor invasiveness, and PRL overexpression is known to cause an increase in the metastatic capability of cancer cell lines.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.