PRG-1/LPPR4 Antibody (368701)

• Reactivity: Hu
• Applications: WB
• Clone: 368701
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: LYOPH

PRG-1/LPPR4 Antibody (368701) Summary

• Immunogen: E. coli-derived recombinant human PRG‑1/LPPR4
  Ser285-Asp715
  Accession # AAO85400
• Specificity: Detects PRG‑1/LPPR4 in direct ELISAs and Western blots.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: LPPR4
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for PRG-1/LPPR4 Antibody (368701)

• LPPR4 lipid phosphate phosphatase-related protein type 4
• LPPR4
• LPR4
• PHP1
• PRG1
• PRG-1
• RP4-788L13.1

Background

PRG-1 (plasticity-related gene-1) is a member of the lipid phosphate phosphatase-related protein (LPR) family. The 715 aa protein has a calculated (unglycosylated) molecular weight of 78 kDa. LPR members have six N-terminal transmembrane sequences and a C-terminal cytoplasmic domain thought to regulate phospholipid phosphatase activity. PRG-1 is expressed on axons in the hippocampus and is upregulated during axonal outgrowth. The C-terminal domain of human PRG-1 (amino acids 285‑715) shares 95% and 94% amino acid identity with mouse and rat PRG-1, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PRG-1/LPPR4 Antibody (MAB2874)(1)

Publication using MAB2874

• A Brosig, J Fuchs, F Ipek, C Kroon, S Schrötter, M Vadhvani, A Polyzou, J Ledderose, M van Diepen, HG Holzhütter, T Trimbuch, N Gimber, J Schmoranze, I Lieberam, C Rosenmund, C Spahn, P Scheerer, M Szczepek, G Leondariti, BJ Eickholt The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches Cell Rep, 2019-11-12;29(7):2028-2040.e8. 2019-11-12 [PMID: 31722215] (Western Blot, Rat)

Bioinformatics

• Gene Symbol: LPPR4
• Uniprot:
  • AAO85400()