Rat Presenilin-1 ELISA Kit (Colorimetric)

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ELISA: Rat Presenilin-1 ELISA Kit (Colorimetric) [NBP3-06977] - Standard Curve Reference.

Product Details

Summary
Reactivity RtSpecies Glossary
Applications ELISA, S-ELISA
Suitable Sample Type
Serum, Plasma, Cell supernatant
Standard Curve Range
125 - 8000 pg/mL
Sensitivity
75 pg/mL

Order Details

Rat Presenilin-1 ELISA Kit (Colorimetric) Summary

Specificity
This kit recognizes Rat Presenilin-1 in samples. No significant cross-reactivity or interference between Rat Presenilin-1 and analogues was observed.
Standard Curve Range
125 - 8000 pg/mL
Sensitivity
75 pg/mL
Assay Type
Sandwich-ELISA
Inter-Assay
4.84
Intra-Assay
5.07
Spike Recovery
89-107 %
Sample Volume
100 ul
Kit Type
ELISA Kit (Colorimetric)
Gene
PSEN1

Applications/Dilutions

Dilutions
  • ELISA
  • Sandwich ELISA

Packaging, Storage & Formulations

Storage
Storage of components varies. See protocol for specific instructions.

Kit Components

Components
  1. Biotinylated Detection Ab Diluent
  2. Certificate of Analysis
  3. Concentrated Biotinylated Detection Ab (100x)
  4. Concentrated HRP Conjugate (100x)
  5. Concentrated Wash Buffer (25x)
  6. HRP Conjugate Diluent
  7. Micro ELISA Plate(Dismountable)
  8. Plate Sealer
  9. Product Description
  10. Reference Standard & Sample Diluent
  11. Reference Standard
  12. Stop Solution
  13. Substrate Reagent

Alternate Names for Rat Presenilin-1 ELISA Kit (Colorimetric)

  • AD3EC 3.4.23.-
  • Alzheimer disease 3
  • EC 3.4.23
  • FAD
  • presenilin 1
  • Presenilin1
  • Presenilin-1
  • Protein S182
  • PS-1
  • PS1presenilin-1
  • PSEN1
  • PSNL1
  • S182

Background

Presenilin (PS) facilitates gamma-secretase cleavage of the beta-amyloid precursor protein and the intramembraneous cleavage of Notch1 (1). Presenilin (PS) is essential for the gamma-cleavage required for the generation of the C terminus of amyloid beta-protein (Abeta). The discovery that a deficiency of presenilin 1 (PS1) decreases the production of amyloid beta-protein (Abeta) identified the presenilins as important mediators of the gamma-secretase cleavage of beta-amyloid precursor protein (APP). It has been shown that two conserved transmembrane (TM) aspartates in PS1 are critical for Abeta production, providing evidence that PS either functions as a required diaspartyl cofactor for gamma-secretase or is itself gamma-secretase. Presenilin 2 (PS2) shares substantial sequence and possibly functional homology with PS1. It has been shown that the two TM aspartates in PS2 are also critical for gamma-secretase activity, providing further evidence that PS2 is functionally homologous to PS1 (2). PS are found primarily within intracellular membranes, including the endoplasmic reticulum (ER) and the trans-Golgi network as well as the plasma membrane. PS are also expressed in most cell types throughout development (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

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Bioinformatics

Gene Symbol PSEN1