Presenilin-1 Products

Antibodies
Presenilin-1 Antibody (APS 11 ...
Presenilin-1 Antibody (APS 11)
NB300-749
Species: Hu, Mu, Rt, Pm
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IP
Host: Mouse Monoclonal
Presenilin-1 Antibody (APS 18 ...
Presenilin-1 Antibody (APS 18)
NB100-74510
Species: Hu, Mu, Rt, Pm
Applications: WB, ELISA, ICC/IF, IHC, IHC-P, IP
Host: Mouse Monoclonal
Presenilin-1 Antibody
Presenilin-1 Antibody
AF149
Species: Hu
Applications: WB, IHC
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
Lysates
Presenilin-1 Knockout HeLa Ce ...
Presenilin-1 Knockout HeLa Cell Ly...
NBP2-65407
Species: Hu
Applications: WB
Presenilin-1 Overexpression L ...
Presenilin-1 Overexpression Lysate...
NBL1-14860
Species: Hu
Applications: WB
Proteins
Recombinant Human Presenilin- ...
Recombinant Human Presenilin-1 Pro...
H00005663-Q01
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
Presenilin-1 Recombinant Prot ...
Presenilin-1 Recombinant Protein A...
NBP2-57002PEP
Species: Hu
Applications: AC
Presenilin-1 Recombinant Prot ...
Presenilin-1 Recombinant Protein A...
NBP1-90245PEP
Species: Hu
Applications: AC
RNAi
Presenilin-1 RNAi
Presenilin-1 RNAi
H00005663-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Presenilin (PS) facilitates gamma-secretase cleavage of the beta-amyloid precursor protein and the intramembraneous cleavage of Notch1 (1). Presenilin (PS) is essential for the gamma-cleavage required for the generation of the C terminus of amyloid beta-protein (Abeta). The discovery that a deficiency of presenilin 1 (PS1) decreases the production of amyloid beta-protein (Abeta) identified the presenilins as important mediators of the gamma-secretase cleavage of beta-amyloid precursor protein (APP). It has been shown that two conserved transmembrane (TM) aspartates in PS1 are critical for Abeta production, providing evidence that PS either functions as a required diaspartyl cofactor for gamma-secretase or is itself gamma-secretase. Presenilin 2 (PS2) shares substantial sequence and possibly functional homology with PS1. It has been shown that the two TM aspartates in PS2 are also critical for gamma-secretase activity, providing further evidence that PS2 is functionally homologous to PS1 (2). PS are found primarily within intracellular membranes, including the endoplasmic reticulum (ER) and the trans-Golgi network as well as the plasma membrane. PS are also expressed in most cell types throughout development (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 5663
Alternate Names
  • Alzheimer disease 3
  • EC 3.4.23
  • PS-1
  • Protein S182
  • S182
  • PSNL1
  • FAD
  • AD3EC 3.4.23.-
  • PS1presenilin-1
  • presenilin 1

Bioinformatics Tool for Presenilin-1

Discover related pathways, diseases and genes to Presenilin-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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Related Presenilin-1 Blog Posts

Check out the latest blog posts on Presenilin-1.
Immunity’s flipside: Microglia promote Alzheimer’s pathology during inflammation
By Jamshed Arslan Pharm.D. Microglia are brain's macrophages. In Alzheimer's disease (AD), microglia clear up protein aggregates called amyloid beta plaques. The connection between immune activation and AD is unclea...    Read more.
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