PPIH Antibody

Product Discontinued

PPIH Antibody Summary

• Immunogen: The immunogen for this antibody was a sequence from 1a.a. to 177a.a. from PPIH(a 177a.a. long protein)
• Localization: Nucleus; nucleolus. Nucleus; nucleoplasm; Cajal body. Also localized to Cajal bodies (coiled bodies). Mitochondrion; mitochondrial matrix.
• Specificity: PPIH
• Clonality: Polyclonal
• Host: Chicken
• Gene: PPIH
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:100-1:2000
• Application Notes: Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000. Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.
• Control:

  PPIH Overexpression Lysate

Reactivity Notes

This antibody is reactive against Human, mouse.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Alternate Names for PPIH Antibody

• cyclophilin H
• CYP20
• CypH
• CYPHpeptidyl prolyl isomerase H (cyclophilin H)
• EC 5.2.1.8
• MGC5016
• peptidyl-prolyl cis-trans isomerase H
• peptidylprolyl isomerase H (cyclophilin H)
• PPIase H
• Rotamase H
• Small nuclear ribonucleoprotein particle-specific cyclophilin H
• SnuCyp-20
• USA-CyP SnuCyp-20
• USA-CYPCYP-20
• U-snRNP-associated cyclophilin SnuCyp-20
• U-snRNP-associated cyclophilin SunCyp-20

Background

PPIases accelerate the folding of proteins. It catalyzes the cis trans isomerization of proline imidic peptide bonds in oligopeptides. Participates in pre mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri snRNP complex. May act as a chaperone. The protein encoded by this gene is a member of the peptidyl prolyl cis trans isomerase (PPIase) family. PPIases catalyze the cis trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PPIH
• Entrez:
  • 10465(Human)
  • 66101(Mouse)
• Uniprot:
  • O43447(Human)