Porcine IL-1 beta/IL-1F2 DuoSet ELISA, 15 Plate

• Reactivity: Po
• Applications: ELISA
• Conjugate: Biotin

Porcine IL-1 beta/IL-1F2 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL1B

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Porcine IL-1 beta/IL-1F2 DuoSet ELISA, 15 Plate

• catabolin
• IL1 beta
• IL-1 beta
• IL-1
• IL1B
• IL-1b
• IL1-BETA
• IL-1F2
• IL1F2IL-1 beta
• interleukin 1, beta
• interleukin-1 beta
• preinterleukin 1 beta
• pro-interleukin-1-beta

Background

IL-1 beta (Interleukin-1 beta) is produced in response to inflammatory agents, infections, or microbial endotoxins. It plays a central role in immune and inflammatory responses, bone remodeling, fever, carbohydrate metabolism, and GH/IGF-I physiology. IL-1 beta dysregulation is implicated in many pathological conditions including sepsis, rheumatoid arthritis, inflammatory bowel disease, acute and chronic myelogenous leukemia, insulin-dependent diabetes mellitus, atherosclerosis, neuronal injury, and aging-related diseases. Intracellular cleavage of the IL-1 beta precursor by Caspase-1/ICE is a key step in the inflammatory response. IL-1 beta binds to IL-1 RI and IL-1 RII. The IL-1 receptor accessory protein (IL-1 RAcP) associates with IL-1 RI and is required for IL-1 RI signal transduction, and IL-1ra is a secreted molecule that functions as a competitive inhibitor of IL-1 bioactivity.

Publications for IL-1 beta/IL-1F2 (DY681)(18)

Publications using DY681

• Zhu, H;Müller, U;Baums, CG;Öhlmann, S; Comparative analysis of the interactions of different Streptococcus suis strains with monocytes, granulocytes and the complement system in porcine blood Veterinary research 2024-02-05 [PMID: 38317258] (Porcine)
• Bonde, CS;Mejer, H;Myhill, LJ;Zhu, L;Jensen, P;Büdeyri Gökgöz, N;Krych, L;Nielsen, DS;Skovgaard, K;Thamsborg, SM;Williams, AR; Dietary seaweed (Saccharina latissima) supplementation in pigs induces localized immunomodulatory effects and minor gut microbiota changes during intestinal helminth infection Scientific reports 2023-12-11 [PMID: 38081984] (Porcine)
• K Obremski, W Trybowski, P Wojtacha, M Gaj?cka, J Tyburski, ? Zielonka The Effect of Zearalenone on the Cytokine Environment, Oxidoreductive Balance and Metabolism in Porcine Ileal Peyer's Patches Toxins (Basel), 2020-05-27;12(6):. 2020-05-27 [PMID: 32471145] (Porcine)
• AMF Matthijs, G Auray, F Boyen, A Schoos, A Michiels, O García-Nic, GT Barut, C Barnier-Qu, V Jakob, N Collin, B Devriendt, A Summerfiel, F Haesebrouc, D Maes Efficacy of three innovative bacterin vaccines against experimental infection with Mycoplasma hyopneumoniae Vet. Res., 2019-11-08;50(1):91. 2019-11-08 [PMID: 31703726] (Porcine)
• Z Cao, Q Yang, M Zheng, H Lv, K Kang, Y Zhang Classical swine fever virus non-structural proteins modulate Toll-like receptor signaling pathways in porcine monocyte-derived macrophages Vet. Microbiol., 2019-01-29;230(0):101-109. 2019-01-29 [PMID: 30827374] (Porcine)
• J Sun, X Pan, LI Christians, XL Yuan, K Skovgaard, DEW Chatterton, SS Kaalund, F Gao, PT Sangild, S Pankratova Necrotizing enterocolitis is associated with acute brain responses in preterm pigs J Neuroinflammation, 2018-06-09;15(1):180. 2018-06-09 [PMID: 29885660] (Porcine)
• M Kalbitz, S Schwarz, B Weber, B Bosch, J Pressmar, FM Hoenes, CK Braun, K Horst, TP Simon, R Pfeifer, P Störmann, H Hummler, F Gebhard, HC Pape, M Huber-Lang, F Hildebrand, TREAT Rese Cardiac Depression in Pigs after Multiple Trauma - Characterization of Posttraumatic Structural and Functional Alterations Sci Rep, 2017-12-19;7(1):17861. 2017-12-19 [PMID: 29259232] (Porcine)
• A Michiels, I Arsenakis, F Boyen, R Krejci, F Haesebrouc, D Maes Efficacy of one dose vaccination against experimental infection with two Mycoplasma hyopneumoniae strains BMC Vet. Res., 2017-08-29;13(1):274. 2017-08-29 [PMID: 28851359] (Porcine)
• Y Xiao, H Yan, H Diao, B Yu, J He, J Yu, P Zheng, X Mao, Y Luo, D Chen Early Gut Microbiota Intervention Suppresses DSS-Induced Inflammatory Responses by Deactivating TLR/NLR Signalling in Pigs Sci Rep, 2017-06-12;7(1):3224. 2017-06-12 [PMID: 28607413] (Porcine)
• EL Sassu, J Frömbling, JC Duvigneau, I Miller, A Müllebner, AM Gutiérrez, T Grunert, M Patzl, A Saalmüller, A von Altroc, A Menzel, M Ganter, J Spergser, M Hewicker-T, J Verspohl, M Ehling-Sch, I Hennig-Pau Host-pathogen interplay at primary infection sites in pigs challenged with Actinobacillus pleuropneumoniae BMC Vet. Res, 2017-02-28;13(1):64. 2017-02-28 [PMID: 28245826] (Porcine)
• Stine B Bering Human milk oligosaccharide effects on intestinal function and inflammation after preterm birth in pigs J. Nutr. Biochem., 2016-11-04;40(0):141-154. 2016-11-04 [PMID: 27889684] (Porcine)
• De Clercq E, Devriendt B, Yin L, Chiers K, Cox E, Vanrompay D The immune response against Chlamydia suis genital tract infection partially protects against re-infection. Vet Res, 2014-09-25;45(0):95. 2014-09-25 [PMID: 25252649] (Porcine)
• The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig. Vet. Res., 2012-04-24;43(1):35. 2012-04-24 [PMID: 22530722] (Porcine)
• Diaz I, Gimeno M, Darwich L, Navarro N, Kuzemtseva L, Lopez S, Galindo I, Segales J, Martin M, Pujols J, Mateu E Characterization of homologous and heterologous adaptive immune responses in porcine reproductive and respiratory syndrome virus infection. Vet. Res., 2012-04-19;43(1):30. 2012-04-19 [PMID: 22515169] (Porcine)
• Husser L, Ruggli N, Summerfield A N(pro) of Classical Swine Fever Virus Prevents Type I Interferon-Mediated Priming of Conventional Dendritic Cells for Enhanced Interferon-alpha Response. J. Interferon Cytokine Res., 2012-02-07;32(5):221-9. 2012-02-07 [PMID: 22313263] (Porcine)
• Miller LC, Zanella EL, Waters WR Cytokine protein expression levels in tracheobronchial lymph node homogenates of pigs infected with pseudorabies virus. Clin. Vaccine Immunol., 2010-03-10;17(5):728-34. 2010-03-10 [PMID: 20219878] (Porcine)
• Inci I, Arni S, Inci D, Zhai W, Hillinger S, Leskosek B, Vogt P, Weder W Impact of topical cooling solution and prediction of pulmonary graft viability from non-heart-beating donors. J. Heart Lung Transplant., 2008-07-21;27(9):1016-22. 2008-07-21 [PMID: 18765195] (Porcine)
• Ashworth MD, Ross JW, Hu J, White FJ, Stein DR, Desilva U, Johnson GA, Spencer TE, Geisert RD Expression of porcine endometrial prostaglandin synthase during the estrous cycle and early pregnancy, and following endocrine disruption of pregnancy. Biol. Reprod., 2006-02-01;74(6):1007-15. 2006-02-01 [PMID: 16452463] (Porcine)

FAQs for IL-1 beta/IL-1F2 (DY681). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: IL1B