PON2 Antibody (453709) [PerCP]

• Reactivity: Hu
• Applications: WB
• Clone: 453709
• Clonality: Monoclonal
• Host: Rat
• Conjugate: PerCP

PON2 Antibody (453709) [PerCP] Summary

• Immunogen: E. coli-derived recombinant human PON2
  Ala30-Leu354
  Accession # NP_000296
• Specificity: Detects endogenous human PON2 in Western blots. In Western blots, this antibody does not cross‑react with recombinant human (rh) PON1 or rhPON3.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: PON2
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for PON2 Antibody (453709) [PerCP]

• A-esterase 2
• Aromatic esterase 2
• EC 3.1.1.2
• EC 3.1.1.81
• paraoxonase 2
• paraoxonase nirs
• PON 2
• PON2
• Serum Aryldialkylphosphatase 2
• serum paraoxonase/arylesterase 2

Background

PON2 encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PON2