PNMA2 Antibody

Western Blot: PNMA2 Antibody [NB100-56634] - analysis of Ma2 in SK-N-SH cell lysate using this antibody.

Product Discontinued

PNMA2 Antibody Summary

• Immunogen: This polyclonal antibody was developed against a mixture of synthetic peptides containing amino acids 143-158 of human Ma2.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PNMA2
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:1000

Reactivity Notes

Cross reacts with Human.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS containing 0.05% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Protein G purified

Alternate Names for PNMA2 Antibody

• MA2KIAA0883
• MM2
• Onconeuronal antigen Ma2
• paraneoplastic antigen MA2,40 kDa neuronal protein
• Paraneoplastic neuronal antigen MM2
• retrotransposon gag domain containing 2
• RGAG2

Background

In patients with cancer, symptoms of limbic and brain-stem dysfunction may result from a para-neoplastic disorder. Two proteins, Ma1 and Ma2, were discovered by presence of autoantibodies against them. Antibodies to Ma1 and Ma2 proteins identify a paraneoplastic disorder that affects the limbic system, brain stem, and cerebellum. These autoantibodies were used to clone Ma2, which codes for a protein (Ma2) that was recognized by serum from the 10 patients, but not by serum from 344 control subjects. Ma2 was selectively expressed by normal brain tissue and by the testicular tumors of the patients. Ma2 shares homology with Ma1, a "brain-testis-cancer" gene related to other para-neoplastic syndromes and tumors.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PNMA2
• Entrez:
  • 10687(Human)
• Uniprot:
  • NP_009188.1(Human)