PNMA2 Products

Description

In patients with cancer, symptoms of limbic and brain-stem dysfunction may result from a para-neoplastic disorder. Two proteins, Ma1 and Ma2, were discovered by presence of autoantibodies against them. Antibodies to Ma1 and Ma2 proteins identify a paraneoplastic disorder that affects the limbic system, brain stem, and cerebellum. These autoantibodies were used to clone Ma2, which codes for a protein (Ma2) that was recognized by serum from the 10 patients, but not by serum from 344 control subjects. Ma2 was selectively expressed by normal brain tissue and by the testicular tumors of the patients. Ma2 shares homology with Ma1, a "brain-testis-cancer" gene related to other para-neoplastic syndromes and tumors.

Bioinformatics

Entrez	10687 Human
Uniprot	AAH62301 Human Q9UL42 Human
Product By Gene ID	10687
Alternate Names	MA2KIAA0883 MM2 Onconeuronal antigen Ma2 paraneoplastic antigen MA2,40 kDa neuronal protein Paraneoplastic neuronal antigen MM2 retrotransposon gag domain containing 2 RGAG2

Research Areas for PNMA2

Find related products by research area and learn more about each of the different research areas below.

Stem Cell Markers