PITRM1 Antibody (1H3) - Azide and BSA Free

Western Blot: PITRM1 Antibody (1H3) [H00010531-M03] - Analysis of PITRM1 expression in A-431 (Cat # L015V1).

• Reactivity: Hu
• Applications: WB, ELISA
• Clone: 1H3
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free

PITRM1 Antibody (1H3) - Azide and BSA Free Summary

• Description: Novus Biologicals Mouse PITRM1 Antibody (1H3) - Azide and BSA Free (H00010531-M03) is a monoclonal antibody validated for use in WB and ELISA. Anti-PITRM1 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: PITRM1 (AAH01150, 1 a.a. ~ 534 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MRPDDKYHEKQAQVEATKLKQKVEALSPGDRQQIYEKGLELRSQQSKPQDASCLPALKVSDIEPTIPVTELDVVLTAGDIPVQYCAQPTNGMVYFRAFSSLNTLPEELRPYVPLFCSVLTKLGCGLLDYREQAQQIELKTGGMSASPHVLPDDSHMDTYEQGVLFSSLCLDRNLPDMMQLWSEIFNNPCFEEEEHFKVLVKMTAQELANGIPDSGHLYASIRAGRTLTPAGDLQETFSGMDQVRLMKRIAEMTDIKPILRKLPRIKKHLLNGDNMRCSVNATPQQMPQTEKAVEDFLRSIGRSKKERRPVRPHTVEKPVPSSSGGDAHVPHGSQVIRKLVMEPTFKPWQMKTHFLMPFPVNYVGECIRTVPYTDPDHASLKILARLMTAKFLHTEIREKGGAYGGGAKLSHNGIFTLYSYRDPNTIETLQSFGKAVDWAKSGKFTQQDIDEAKLSVFSTVDAPVAPSDKGMDHFLYGLSDEMKQAHREQLFAVSHDKLLAVSDRYLGTGKSTHGLAILGPENPKIAKDPSWIIR
• Specificity: Reacts with pitrilysin metallopeptidase 1.
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: PITRM1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: This antibody is reactive against cell lysate in western blot and recombinant protein in ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for PITRM1 Antibody (1H3) - Azide and BSA Free

• EC 3.4.24
• EC 3.4.24.-
• hPreP
• Metalloprotease 1
• MGC138192
• MGC141929
• pitrilysin metallopeptidase 1
• Pitrilysin metalloproteinase 1mitochondrial
• PreP

Background

ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides. Specific for peptides in the range of 10 to 65 residues. Able to degrade amyloid beta A4 (APP) protein when it accumulates in mitochondrion, suggesting a link with Alzheimer disease. Shows a preference for cleavage after small polar residues and before basic residues, but without any positional preference

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PITRM1 Antibody (H00010531-M03)(1)

Publication using H00010531-M03

• Sutandy FXR, Gö beta ner I, Tascher G, Münch C A cytosolic surveillance mechanism activates the mitochondrial UPR Nature 2023-06-01 [PMID: 37286597] (WB, Human)
  
  Details:
  1:500 WB dilution

Bioinformatics

• Gene Symbol: PITRM1
• Entrez:
  • 10531(Human)
• Uniprot:
  • AAH01150(Human)