PIASy Antibody Blocking Peptide

Product Discontinued

PIASy Antibody Blocking Peptide Summary

• Description: A blocking peptide containing 19 amino acids near the amino terminus of human PIAS4.

  Source: Synthetic

  (Accession #: NP_056981)

• Source: Synthetic
• Protein/Peptide Type: Antibody Blocking Peptide
• Gene: PIAS4
• Purity: N/A

Applications/Dilutions

• Dilutions:
  • Antibody Competition
• Application Notes: This peptide is useful as a blocking peptide for NBP1-77161.
  
  For further blocking peptide related protocol, click here.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin.
• Preservative: 0.02% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: N/A

Alternate Names for PIASy Antibody Blocking Peptide

• E3 SUMO-protein ligase PIAS4
• FLJ12419
• MGC35296
• Piasg
• PIAS-gamma
• PIASY
• Protein inhibitor of activated STAT protein 4
• Protein inhibitor of activated STAT protein gamma
• protein inhibitor of activated STAT protein PIASy
• protein inhibitor of activated STAT, 4
• zinc finger, MIZ-type containing 6
• ZMIZ6

Background

The IL-6-type family of cytokines, which includes IL-6 as well as a number of similar cytokines and growth factors, plays a significant role in regulating gene activation, proliferation and differentiation. Transcription factors of the Stat family are known to be involved in this signal transduction pathway, undergoing phosphorylation, dimerization and translocation to the nucleus upon activation. PIAS 1, for protein inhibitor of activated Stat1 (also designated Gu/RNA helicase II binding protein), binds specifically to Stat1, blocking Stat1 DNA-binding activity and inhibiting Stat1-mediated gene activation. PIAS 1 also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS 3 similarly binds specifically to Stat3, blocking Stat3 DNA-binding activity and inhibiting Stat3-mediated gene activation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Bioinformatics

• Gene Symbol: PIAS4