PIASy Products

Description

The IL-6-type family of cytokines, which includes IL-6 as well as a number of similar cytokines and growth factors, plays a significant role in regulating gene activation, proliferation and differentiation. Transcription factors of the Stat family are known to be involved in this signal transduction pathway, undergoing phosphorylation, dimerization and translocation to the nucleus upon activation. PIAS 1, for protein inhibitor of activated Stat1 (also designated Gu/RNA helicase II binding protein), binds specifically to Stat1, blocking Stat1 DNA-binding activity and inhibiting Stat1-mediated gene activation. PIAS 1 also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS 3 similarly binds specifically to Stat3, blocking Stat3 DNA-binding activity and inhibiting Stat3-mediated gene activation.

Bioinformatics

Entrez	51588 Human 59004 Mouse
Uniprot	AAH66895 Human NM_015897 Human NP_056981 Human Q8N2W9 Human
Product By Gene ID	51588
Alternate Names	E3 SUMO-protein ligase PIAS4 FLJ12419 MGC35296 PIASG Piasg PIAS-gamma PIASY PIASy Protein inhibitor of activated STAT protein 4 Protein inhibitor of activated STAT protein gamma protein inhibitor of activated STAT protein PIASy protein inhibitor of activated STAT, 4 zinc finger, MIZ-type containing 6 ZMIZ6