PIASy Products

Antibodies
PIASy Antibody
PIASy Antibody
NB600-1318
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
PIASy Antibody
PIASy Antibody
NBP1-31215
Species: Hu, Mu, Bovine, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
PIASy Antibody
PIASy Antibody
NBP1-77161
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
PIASy Overexpression Lysate ( ...
PIASy Overexpression Lysate (Native)
NBL1-14388
Applications: WB
Proteins
PIASy Recombinant Protein
PIASy Recombinant Protein
H00051588-P01
Species: Hu
Applications: WB, ELISA, PA
PIASy Peptide
PIASy Peptide
NBP1-77161PEP
Species: Hu
Applications: AC
RNAi
PIASy RNAi
PIASy RNAi
H00051588-R01
Species: Hu

Description

The IL-6-type family of cytokines, which includes IL-6 as well as a number of similar cytokines and growth factors, plays a significant role in regulating gene activation, proliferation and differentiation. Transcription factors of the Stat family are known to be involved in this signal transduction pathway, undergoing phosphorylation, dimerization and translocation to the nucleus upon activation. PIAS 1, for protein inhibitor of activated Stat1 (also designated Gu/RNA helicase II binding protein), binds specifically to Stat1, blocking Stat1 DNA-binding activity and inhibiting Stat1-mediated gene activation. PIAS 1 also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS 3 similarly binds specifically to Stat3, blocking Stat3 DNA-binding activity and inhibiting Stat3-mediated gene activation.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Product By Gene ID 51588
Alternate Names
  • PIASy
  • Protein inhibitor of activated STAT protein gamma
  • PIASG
  • Protein inhibitor of activated STAT protein 4
  • zinc finger, MIZ-type containing 6
  • ZMIZ6
  • protein inhibitor of activated STAT protein PIASy
  • Piasg
  • E3 SUMO-protein ligase PIAS4
  • PIASY
  • MGC35296
  • FLJ12419
  • PIAS-gamma
  • protein inhibitor of activated STAT, 4

Bioinformatics Tool for PIASy

Discover related pathways, diseases and genes to PIASy. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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