Phospholipid Scramblase 1/PLSCR1 Antibody (875327) [Alexa Fluor® 594]

• Applications: WB, ICC/IF
• Clone: 875327
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

Phospholipid Scramblase 1/PLSCR1 Antibody (875327) [Alexa Fluor® 594] Summary

• Immunogen: E. coli-derived recombinant human Phospholipid Scramblase 1/PLSCR1
  Met1-Pro84
  Accession # O15162
• Specificity: Detects human Phospholipid Scramblase 1/PLSCR1 in ELISA.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

PLSCR1 (phospholipid scramblase 1) is an approximately 37 kDa, type II transmembrane protein that is a member of the Ca2+-dependent phospholipid scramblase family that regulates phospholipid asymmetry of membranes. It is most highly expressed on erythrocytes and platelets, and plays roles in exocytosis and apoptosis. PLSCR1 also has nuclear activity, for example, as an activator of genes in response to interferons. The 318 amino acid (aa) human PLSCR1 contains a 288 aa cytoplasmic domain with three SH3-binding and two WW-binding adaptor domains, three phosphorylation sites, four potential palmitoylation sites (regulating localization to the nucleus or plasma membrane) and a nuclear localization signal, followed by a transmembrane domain and a short extracellular domain. The N-terminus of human PLSCR1 (aa 1-84) shares <60% aa sequence identity with mouse and rat PLSCR1. Potential isoforms have a downstream start site without (311 aa) or with (186 aa) divergence after aa 192, or an upstream start site with divergence of 1 or 11 aa after aa 192 (205, 215 aa).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.