PGLYRP4/PGRP-I beta Antibody (186C426) - Azide and BSA Free

Western Blot: PGLYRP4/PGRP-I beta Antibody (186C426) - Azide Free [NBP2-33246] - Analysis in cell lysates from human brain using a dilution of 2 ug/ml.

• Reactivity: Hu
• Applications: WB, Flow, ICC/IF
• Clone: 186C426
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: 0.5 mg/ml

PGLYRP4/PGRP-I beta Antibody (186C426) - Azide and BSA Free Summary

• Description: Novus Biologicals Mouse PGLYRP4/PGRP-I beta Antibody (186C426) - Azide and BSA Free (NB100-56721) is a monoclonal antibody validated for use in WB and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: This antibody was developed against KLH-conjugated synthetic peptide corresponding to amino acids 95-110 of human PGRP-1 beta.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: PGLYRP4
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Flow (Cell Surface) reported in scientific literature (Uehara et al (2005))
  • Immunocytochemistry/ Immunofluorescence reported in scientific literature (Uehara et al (2005))
  • Western Blot 2 ug/ml

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: No Preservative
• Concentration: 0.5 mg/ml
• Purity: Protein G purified

Alternate Names for PGLYRP4/PGRP-I beta Antibody (186C426) - Azide and BSA Free

• peptidoglycan recognition protein 4
• peptidoglycan recognition protein I beta
• Pglyrp-1 beta
• PGLYRP4
• PGRPI beta
• PGRP-I beta
• PGRP-I-beta

Background

The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1,2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-I alpha, and PGRP-I beta) define a new family of human pattern recognition molecules (3). PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood (4-5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PGLYRP4