Applications: WB, IP
Host: Mouse Monoclonal
Host: Goat Polyclonal
The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria. Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria (1,2) and, thus, it is an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-I alpha, and PGRP-I beta) define a new family of human pattern recognition molecules (3). PGRP-L is primarily expressed in the liver. Although liver is not considered a primary immune organ, liver participates in host defenses by producing acute phase proteins (by hepatocytes) in response to infections and by clearing microorganisms from blood (4-5).
|Product By Gene ID
- peptidoglycan recognition protein I beta
- peptidoglycan recognition protein 4
PTMs for PGLYRP4/PGRP-I beta
Learn more about PTMs related to PGLYRP4/PGRP-I beta.Cleavage
Bioinformatics Tool for PGLYRP4/PGRP-I beta
Discover related pathways, diseases and genes to PGLYRP4/PGRP-I beta. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.