PERP Antibody

Product Discontinued

PERP Antibody Summary

• Immunogen: Amino acids 37-50 of the human PERP protein.
• Localization: Cell Membrane; desmosome; multi-pass membrane protein.
• Specificity: Reacts with residues 37-50 of the human PERP protein. This region is in the first extracellular loop of the protein.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: PERP
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500 -1:1000
• Application Notes: In Western blot, a band is seen around 23 kDa representing PERP.
  
  The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
• Theoretical MW: 21 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Cross reacts with Human. Mouse reactivity reported in scientific literature (PMID:19158346)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for PERP Antibody

• dJ496H19.1
• KCP1KCP-1
• Keratinocyte-associated protein 1
• KRTCAP11110017A08Rik
• p53 apoptosis effector related to PMP22
• p53 apoptosis effector related to PMP-22
• P53-induced protein PIGPC1
• PERP, TP53 apoptosis effector
• PIGPC1RP3-496H19.1
• THWkeratinocytes associated protein 1
• Transmembrane protein THW

Background

The p53 tumor suppressor activates either cell cycle arrest or apoptosis in response to cellular stress. A novel gene, PERP, is expressed in a p53-dependent manner and at high levels in apoptotic cells compared with G(1)-arrested cells. PERP induction is linked to p53-dependent apoptosis and is directly activated by p53. These data suggest that PERP is a novel effector of p53-dependent apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for PERP Antibody (NB500-231)(1)

Publication using NB500-231

• Singaravelu K, Devalaraja-Narashimha K, Lastovica B et al. PERP, a p53 pro-apoptotic target, mediates apoptotic cell death in renal ischemia. Am J Physiol Renal Physiol :90438.92008. 2009-01-01 [PMID: 19158346] (WB, Mouse)

Bioinformatics

• Gene Symbol: PERP
• Entrez:
  • 64065(Human)