PDE8B Antibody

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Immunohistochemistry-Paraffin: PDE8B Antibody [NB110-40459] - Analysis of anti-PDE8B antibody with human thyroid at concentration 5 ug/ml.

Product Details

Summary
Reactivity Hu, Mk, Pm, Ca, EqSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.3 mg/ml

Order Details

PDE8B Antibody Summary

Immunogen
Synthetic 16 amino acid peptide from internal region of human PDE8B.
Epitope
internal domain of human
Specificity
Human PDE8B. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Canine (94%), Equine (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PDE8B
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 5 ug/ml

Reactivity Notes

Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Mouse (88%), Rat (88%), Bat (88%), Elephant (88%), Porcine (88%), Opossum (81%), Platypus (81%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
0.3 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PDE8B Antibody

  • 3'-5' cyclic nucleotide phosphodiesterase 8B
  • ADSD
  • Cell proliferation-inducing gene 22 protein
  • EC 3.1.4.17
  • FLJ11212
  • high affinity cAMP-specific and IBMX-insensitive 3'-5'-cyclic phosphodiesterase8B
  • hsPDE8B
  • phosphodiesterase 8B
  • PPNAD3

Background

Cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of the 5-prime,3-prime-cyclic nucleotides cAMP and cGMP to the corresponding nucleoside 5-prime-monophosphates. Mammalian PDEs have been grouped into several families based on substrate affinities, inhibitor sensitivities, mode of regulation, and amino acid sequence homologies. The PDE8 family contains high-affinity cAMP-specific, IBMX (3-isobutyl-1-methyl-xanthine)-insensitive PDEs. All PDEs share a conserved C-terminal catalytic region and a variable N-terminal domain that presumably accounts for the distinctive regulatory properties unique to the individual families. PDE8B exhibits cAMP PDE activity which was not inhibited by various PDE inhibitors, including IBMX. The cAMP hydrolytic activity was unaffected by cGMP, and no cGMP PDE hydrolysis has been detected. Northern blot analysis indicated that the 4.2-kb PDE8B mRNA was expressed at the highest levels in thyroid, and at lower levels in brain, spinal cord, and placenta.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Array NB110-40459

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Bioinformatics

Gene Symbol PDE8B
Entrez