PDE1C Antibody

Images

 
Western Blot: PDE1C Antibody [NB300-672] - Rat brain on SDS page. Aproximately 50-60 ug total rat brain homogenate/lane. 1:250 antibody dilution in DiluOBuffer. Lane 1. Rabbit, Lane 2: Rabbit
Immunohistochemistry: PDE1C Antibody [NB300-672] - Human ovarian medulla tissue. 1:1500 antibody dilution
Western Blot: PDE1C Antibody [NB300-672] - 1:500 antibody dilution in DiluOBuffer.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.75 mg/ml

Order Details

PDE1C Antibody Summary

Immunogen
Synthetic peptide corresponding to unique amino acid sequence on PDE1C gene.
Specificity
The does not cross react with PDE1A, PDE1B or other PDEs.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PDE1C
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:250-1:500
  • ELISA 1:10000
  • Immunocytochemistry/Immunofluorescence 1:100
  • Immunohistochemistry 1:40-1:100
  • Immunohistochemistry-Paraffin 1:40-1:100
  • Immunoprecipitation 1:200
Application Notes
Immunoprecipitation and Western Blot: This antibody labels multiple bands in the 70-87 kDa range all believed to be various PDE1C variants. Optimal dilutions and concentrations should be determined by the end user.
Publications
Read Publication using NB300-672.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Tris/Glycine buffer, pH 7.4-7.8, HEPES,BSA 0.5%, glycerol 30%.
Preservative
0.02% Sodium Azide
Concentration
0.75 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PDE1C Antibody

  • calmodulin-dependent (70kD)
  • EC 3.1.4
  • phosphodiesterase 1C, calmodulin-dependent 70kDa

Background

PDE1C is a phosphodiesterase activated by the binding of calmodulin in the presence of calcium. Cyclic nucleotides are hydrolyzed and compartmentalized by a family of enzymes called phosphodiesterases. In mammals at least 11 different families of PDEs can be discriminated (PDE1-11) based on their kinetic properties and inhibition to various pharmacological agents. Three different PDE1 genes have been identified (PDE1A, PDE1B, PDE1C). The enzymes of the PDE1A and PDE1B have higher affinity for cGMP than for cAMP, where as, PDE1C has high affinity for both cAMP and cGMP. Calcium-Calmodulin stimulates the activity of each of these enzymes several-fold. The PDE1C gene codes a family of proteins (variants) that differ from each other at amino and carboxy termini of the protein. The tissue distribution of PDE1C is different from other PDE1 gene family members.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for PDE1C Antibody (NB300-672)(1)

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for PDE1C Antibody (NB300-672) (0)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol PDE1C
Entrez