PDE6A Antibody

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Immunohistochemistry-Paraffin: PDE6A Antibody [NB110-40461] - Analysis of anti-PDE6A / PDE6 Alpha antibody with human eye, retina at concentration 10 ng/ml.

Product Details

Summary
Reactivity Hu, Mu, Rt, Ha, Mk, Pm, Ca, RbSpecies Glossary
Applications IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.23 mg/ml

Order Details

PDE6A Antibody Summary

Immunogen
Synthetic 18 amino acid peptide from N-terminus of human PDE6A / PDE6 Alpha.
Localization
Cell membrane; Lipid-anchor; Cytoplasmic side.
Specificity
Human PDE6A / PDE6 Alpha. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Predicted Species
Canine (94%), Rabbit (94%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PDE6A
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin 10 ng/ml

Reactivity Notes

Gorilla, Gibbon, Marmoset. Predicted cross-reactivity based on sequence identity: Panda (94%), Bovine (89%), Bat (89%), Elephant (89%), Equine (83%), Opossum (83%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
0.23 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PDE6A Antibody

  • CGPR-A
  • EC 3.1.4
  • EC 3.1.4.35
  • GMP-PDE alpha
  • PDE V-B1
  • PDEAcGMP phosphodiesterase alpha subunit
  • phosphodiesterase 6A, cGMP-specific, rod, alpha
  • rod cGMP-specific 3'-5'-cyclic phosphodiesterase subunit alpha
  • rod photoreceptor cGMP phosphodiesterase alpha subunit
  • RP43

Background

This gene encodes the cyclic-GMP (cGMP)-specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. The phosphodiesterase 6 holoenzyme is a heterotrimer composed of an alpha, beta, and two gamma subunits. cGMP is an important regulator of rod cell membrane current, and its dynamic concentration is established by phosphodiesterase 6A cGMP hydrolysis and guanylate cyclase cGMP synthesis. The protein is a subunit of a key phototransduction enzyme and participates in processes of transmission and amplification of the visual signal. Mutations in this gene have been identified as one cause of autosomal recessive retinitis pigmentosa.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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FAQs for PDE6A Antibody (NB110-40461). (Showing 1 - 1 of 1 FAQ).

  1. Could you by any chance provide more information on the antibody in immunohistochemistry? The picture shown in human is not clear and does not look specific. We are looking to try this out in frozen sections in dog. If you cannot provide this information, would it be possible to obtain a small aliquot for testing before purchasing your antibody? We have tried the PDE6B antibody and it works very cleanly in dog retina, and wish to add to this for a publication, to get PDE6A staining.
    • PDE6A in dogs shares 95% homology so this antibody is predicted to cross-react with canine samples, however, Novus is not able to offer free samples at this time. Since this antibody is predicted to work in canine samples, if you would like to test an antibody in an untested species and share your results with us, I can recommend our Innovator's Reward(TM) program. Our Innovator’s Reward(TM) program was created to allow researchers the opportunity to try our primary antibodies in an untested species or application, without the financial risk of failure. To participate you simply submit an online review detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Reviews may also be submitted by emailing innovators@novusbio.com.

Secondary Antibodies

 

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Bioinformatics

Gene Symbol PDE6A
Entrez
Uniprot