PAK4 Antibody

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Western Blot: PAK4 Antibody [NBP1-45763] - Western blot analysis of PAK4 expression with COS cell lysate.

Product Details

Summary
Reactivity Hu, Mu, Rt, HaSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

PAK4 Antibody Summary

Immunogen
Synthetic peptide corresponding to the N-terminus of human Pak4 (BAF84528).
Specificity
The antibody recognizes ~60-70 kDa Pak4 in samples of human, mouse, and rat origins.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
PAK4
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
Application Notes
Western blot analysis (0.5-4 ug/ml). However, the optimal conditions should be determined individually. The antibody recognizes ~60-70 kDa Pak4 in samples of human, mouse, and rat origins. The antibody does not cross-react with other Paks. Reactivity to other species has not been tested.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2), 0.5% BSA and 30% Glycerol
Preservative
0.01% Thimerosal
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PAK4 Antibody

  • EC 2.7.11
  • EC 2.7.11.1
  • KIAA1142
  • p21 protein (Cdc42/Rac)-activated kinase 4
  • p21(CDKN1A)-activated kinase 4
  • p21-activated kinase 4
  • PAK4
  • PAK-4
  • protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
  • serine/threonine-protein kinase PAK 4

Background

p21-activated kinase 4 (PAK4) is a member of a family of serine/threonine protein kinase defined by their interaction with the small GTPases, Cdc42 and Rac (1-2). The PAK proteins can be essentially divided into two categories, groups I (PAK1, PAK2 and PAK3) and group II (PAK4, PAK5 and PAK6), based on their structures (3). PAK4 has been shown to regulate cytoskeletal organization and to protect cells from apoptosis induced by multiple stimuli, including serum withdrawal, tumor necrosis factor- (TNF) treatment, or UV irradiation (4). PAK4 expression is elevated in many cancer cell lines, and activated PAK4 is highly transforming, suggesting an important role in tumorigenesis (5).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol PAK4
Entrez
Uniprot