PAK4 Products

Description

p21-activated kinases (PAKs) belong to the family of serine/threonine kinases involved in the control of various cellular processes, including the cell cycle, dynamics of the cytoskeleton, apoptosis, oncogenic transformation, and transcription. All PAK family members are characterized by the presence of p21-binding domain. p21-activated kinases are regulated by the small GTP-binding proteins Rac and Cdc42, and lipids, which stimulate autophosphorylation and phosphorylation of exogenous substrates. Serine (Ser-474) is the likely autophosphorylation site in the kinase domain of PAK4 in vivo. Phosphospecific antibodies directed against serine 474 detect activated PAK4 on the Golgi membrane when PAK4 is co-expressed with activated Cdc42. Current data strongly implicates PAK-4 in oncogenesis. PAK4 is frequently overexpressed in human tumor cell lines of various tissue origins.

Bioinformatics

Uniprot	AAH02921 Human AB032968 Human BAF84528 Human NM_001014831 Human NM_001014832 Human NM_001014833 Human NM_001014834 Human NM_001014835 Human NM_005884 Human NP_001014831 Human NP_001014832 Human NP_005875 Human O96013 Human
Product By Gene ID	10298
Alternate Names	EC 2.7.11 EC 2.7.11.1 KIAA1142 p21 protein (Cdc42/Rac)-activated kinase 4 p21(CDKN1A)-activated kinase 4 p21-activated kinase 4 PAK-4 protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs serine/threonine-protein kinase PAK 4

Research Areas for PAK4

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Phospho-Specific
Protein Kinase