PAK4 Products

Antibodies
PAK4 Antibody (1C7)
PAK4 Antibody (1C7)
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
PAK4 Antibody
PAK4 Antibody
AF4178
Species: Hu, Mu, Rt
Applications: WB
Host: Goat Polyclonal
PAK4 Antibody
PAK4 Antibody
NBP1-77236
Species: Hu
Applications: WB, ELISA, IHC, IHC-P, IF
Host: Rabbit Polyclonal
Lysates
PAK4 Overexpression Lysate (N ...
PAK4 Overexpression Lysate (Native)
NBL1-14080
Applications: WB
PAK4 Overexpression Lysate (N ...
PAK4 Overexpression Lysate (Native)
NBP2-09153
Applications: WB
PAK4 Overexpression Lysate (N ...
PAK4 Overexpression Lysate (Native)
NBL1-14081
Applications: WB
Proteins
PAK4 Recombinant Protein
PAK4 Recombinant Protein
NBC1-18517
Species: Hu
Applications: PAGE
PAK4 Peptide
PAK4 Peptide
NBP1-77236PEP
Species: Hu
Applications: AC
PAK4 Recombinant Protein
PAK4 Recombinant Protein
NBP1-99458
RNAi
PAK4 RNAi
PAK4 RNAi
H00010298-R11
Species: Hu
PAK4 RNAi
PAK4 RNAi
H00010298-R12
Species: Hu
PAK4 RNAi
PAK4 RNAi
H00010298-R07
Species: Hu

Description

p21-activated kinases (PAKs) belong to the family of serine/threonine kinases involved in the control of various cellular processes, including the cell cycle, dynamics of the cytoskeleton, apoptosis, oncogenic transformation, and transcription. All PAK family members are characterized by the presence of p21-binding domain. p21-activated kinases are regulated by the small GTP-binding proteins Rac and Cdc42, and lipids, which stimulate autophosphorylation and phosphorylation of exogenous substrates. Serine (Ser-474) is the likely autophosphorylation site in the kinase domain of PAK4 in vivo. Phosphospecific antibodies directed against serine 474 detect activated PAK4 on the Golgi membrane when PAK4 is co-expressed with activated Cdc42. Current data strongly implicates PAK-4 in oncogenesis. PAK4 is frequently overexpressed in human tumor cell lines of various tissue origins.

Bioinformatics

Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 10298
Alternate Names
  • EC 2.7.11.1
  • EC 2.7.11
  • p21-activated kinase 4
  • KIAA1142
  • PAK-4
  • serine/threonine-protein kinase PAK 4
  • p21(CDKN1A)-activated kinase 4
  • protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
  • p21 protein (Cdc42/Rac)-activated kinase 4

Research Areas for PAK4

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Phospho-Specific
Protein Kinase

PTMs for PAK4

Learn more about PTMs related to PAK4.

Phosphorylation
Dephosphorylation
Ubiquitination

Bioinformatics Tool for PAK4

Discover related pathways, diseases and genes to PAK4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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