p53R2 Antibody [mFluor Violet 610 SE]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, ICC/IF, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: mFluor Violet 610 SE

p53R2 Antibody [mFluor Violet 610 SE] Summary

• Immunogen: Antibody was raised against a 16 amino acid peptide near the amino terminus of human p53R2. The immunogen is located within the first 50 amino acids of p53R2. Amino Acid Squence: GDPERPEAAGLDQDER
• Specificity: At least six isoforms of p53R2 are known to exist; this antibody will detect all but the largest isoform.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RRM2B
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Peptide affinity purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for p53R2 Antibody [mFluor Violet 610 SE]

• EC 1.17.4.1
• MGC102856
• MGC42116
• MTDPS8A
• MTDPS8B
• p53-inducible ribonucleotide reductase small subunit 2 homolog
• p53-inducible ribonucleotide reductase small subunit 2-like protein
• p53R2
• P53R2DKFZp686M05248
• PEOA5
• ribonucleoside-diphosphate reductase subunit M2 B
• ribonucleotide reductase M2 B (TP53 inducible)
• RRM2B
• TP53-inducible ribonucleotide reductase M2 B

Background

The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 signaling, including p53R2, Chk2, p53AIP1, Noxa, PIDD, and PID/MTA2, were recently discovered. p53R2 is a p53 inducible gene that contains a p53 binding sequence and encodes a subunit of the enzyme ribonucleotide reductase. p53R2 is induced by the reagents, ultraviolet and g-irradiation that cause DNA damages. The product of p53R2 gene is directly involved in the p53 checkpoint for repair of damaged DNA. The isoform of the p53 family member p73 also induces p53R2 expression. p53R2 is an important target of p53 for tumour suppression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RRM2B