Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
PBS [pH7.2] with 30% glycerol and 0.5% BSA
Immunogen affinity purified
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publications using NB100-1913 in the following applications:
The p53 tumor suppressor protein plays a major role in cellular response to DNA damage and other genomic aberrations. The activation of p53 can lead to either cell cycle arrest and DNA
repair or apoptosis. p53 is phosphorylated at multiple sites in vivo and by several different protein kinases in vitro. p53 can apparently be phosphorylated by ATM, ATR, and DNA-PK at Ser15; the phosphorylation impairs the ability of MDM2 to bind p53, promoting both the accumulation and functional activation of p53 in response to DNA damage.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for p53 Antibody (NB100-1913). (Showing 1 - 1 of 1 FAQs).
This product is powder or liquid? Could you suggest me the concentration for human sample (IHC-P)?
I am showing that this product comes in liquid form at 0.5 mg/mL and the suggested concentration for IHC is 20 ug/mL. This of course is just a guide and must be optimized by you based on how highly expressed the protein is in your samples.
PRMT6: One Function, Many Roles Protein arginine methylation is a prevalent posttranslational modification in eukaryotic cells. It regulates RNA processing, trafficking and nascent pre-RNA metabolism, receptor-mediated signal transduction, and transcriptional activation processes. P... Read full blog post.
p14 ARF is an Important Tumor Suppressor The p14ARF (Alternative Reading Frame) tumor suppressor is a protein product of the alternative reading frame (ARF) of the human INK4a locus which regulates a series of cell cycle regulatory proteins to promote cell cycle arrest in response to abnorma... Read full blog post.