P11 Antibody - BSA Free

Western Blot: P11 Antibody - BSA Free [NBP3-46927] - Mouse lung tissue were subjected to SDS PAGE followed by western blot with (P11 antibody) at dilution of 1:600

Immunohistochemistry: P11 Antibody - BSA Free [NBP3-46927] - Immunohistochemistry of paraffin-embedded human breast cancer using (P11 antibody) at dilution of 1:100

• Reactivity: Hu, Mu, Rt
• Applications: WB, ELISA, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

P11 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit P11 Antibody - BSA Free (NBP3-46927) is a polyclonal antibody validated for use in IHC, WB and ELISA. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: 26 serine protease. (Uniprot# P21128)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ENDOU
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry 1:20-1:200
  • Western Blot 1:500-1:5000
• Application Notes: Theoretical Molecular Weight is 35-40 kDa

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS, 50% Glycerol, pH (7.3)
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for P11 Antibody - BSA Free

• EC 3.1
• endonuclease, polyU-specific
• MGC133268
• P11,26 serine protease
• Placental protein 11
• poly(U)-specific endoribonuclease
• PP1122 serine protease
• Protein endoU
• PRSS26
• Uridylate-specific endoribonuclease

Background

p11 increases localization of 5-HT1B receptors at the cell surface. It is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ENDOU