Orexin A/Hypocretin-1 Antibody (97505) [DyLight 650]

• Reactivity: Hu, Mu
• Applications: IHC
• Clone: 97505
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: DyLight 650

Orexin A/Hypocretin-1 Antibody (97505) [DyLight 650] Summary

• Immunogen: KLH-coupled human Orexin A/Hypocretin‑1 synthetic peptide
  Accession # O43612
• Specificity: Detects human and mouse Orexin A/Hypocretin‑1. In dot blots, no cross-reactivity with recombinant human Orexin B is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: HCRT
• Purity: Protein A or G purified from ascites

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from ascites

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Orexin A/Hypocretin-1 Antibody (97505) [DyLight 650]

• HCRT
• Hcrt1
• hypocretin (orexin) neuropeptide precursor
• Hypocretin1
• Hypocretin-1
• NRCLP1
• Orexin A
• orexin
• OXHcrt
• PPORX
• PPOXHypocretin

Background

FUNCTION: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum; rough endoplasmic reticulum (By similarity). Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses (By similarity). SIMILARITY: Belongs to the orexin family.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HCRT