Orexin A/Hypocretin-1 Antibody (97505) [Unconjugated]

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Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications IHC
Clone
97505
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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Orexin A/Hypocretin-1 Antibody (97505) [Unconjugated] Summary

Immunogen
KLH-coupled human Orexin A/Hypocretin‑1 synthetic peptide
Accession # O43612
Specificity
Detects human, mouse, and rat Orexin A/Hypocretin‑1. In dot blots, no cross-reactivity with recombinant human Orexin B is observed.
Source
N/A
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
HCRT
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 8-25 ug/mL
Publications
Read Publications using
MAB763 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Orexin A/Hypocretin-1 Antibody (97505) [Unconjugated]

  • HCRT
  • Hcrt1
  • hypocretin (orexin) neuropeptide precursor
  • Hypocretin1
  • Hypocretin-1
  • NRCLP1
  • Orexin A
  • orexin
  • OXHcrt
  • PPORX
  • PPOXHypocretin

Background

Orexin A and Orexin B are neuropeptide hormones derived from proteolytic processing of the Orexin precursor protein. Orexins are released from the hypothalamus and are involved in the regulation of sleeping patterns, feeding, and metabolism. The synthetic peptide immunogen corresponds to amino acid 34 - 66 of the human Orexin precursor (accession #O43612) (1).
  1. Sakurai, T. et al. (1998) Cell 92:573.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Orexin A/Hypocretin-1 Antibody (MAB763)(11)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Alpaca, Canine.

We have publications tested in 4 applications: ICC, IHC, IHC-Fr, IHC-P.


Filter By Application
ICC
(1)
IHC
(3)
IHC-Fr
(5)
IHC-P
(2)
All Applications
Filter By Species
Human
(1)
Mouse
(6)
Rat
(2)
Alpaca
(1)
Canine
(1)
All Species
Showing Publications 1 - 10 of 11. Show All 11 Publications.
Publications using MAB763 Applications Species
K Ogawa, H Suga, C Ozone, M Sakakibara, T Yamada, M Kano, K Mitsumoto, T Kasai, Y Kodani, H Nagasaki, N Yamamoto, D Hagiwara, M Goto, R Banno, Y Sugimura, H Arima Vasopressin-secreting neurons derived from human embryonic stem cells through specific induction of dorsal hypothalamic progenitors Sci Rep, 2018;8(1):3615. 2018 [PMID: 29483626] (ICC, Human) ICC Human
G Liguori, C Squillacio, L Assisi, A Pelagalli, A Vittoria, A Costagliol, N Mirabella Potential role of orexin A binding the receptor 1 for orexins in normal and cryptorchid dogs BMC Vet. Res., 2018;14(1):55. 2018 [PMID: 29482574] (IHC, Canine) IHC Canine
G Liguori, C Squillacio, L Assisi, N Mirabella, E Langella, A Costagliol, A Vittoria Localization of orexin B and receptor 2 for orexins in testicular cytotypes of the camelid alpaca (Vicugna pacos) Reprod. Domest. Anim, 2017;0(0):. 2017 [PMID: 28181310] (IHC, Alpaca) IHC Alpaca
Sears, Robert M, Fink, Ann E, Wigestrand, Mattis B, Farb, Claudia, de Lecea, Luis, Ledoux, Joseph E Orexin/hypocretin system modulates amygdala-dependent threat learning through the locus coeruleus. Proc Natl Acad Sci U S A, 2013;110(50):20260-5. 2013 [PMID: 24277819] (IHC, Rat) IHC Rat
Panossian L, Fenik P, Zhu Y SIRT1 regulation of wakefulness and senescence-like phenotype in wake neurons. J. Neurosci., 2011;31(11):4025-36. 2011 [PMID: 21411645] (IHC-Fr, Mouse) IHC-Fr Mouse
Naidoo N, Zhu J, Zhu Y, Fenik P, Lian J, Galante R, Veasey S Endoplasmic reticulum stress in wake-active neurons progresses with aging. Aging Cell, 2011;10(4):640-9. 2011 [PMID: 21388495] (IHC-Fr, Mouse) IHC-Fr Mouse
Plaza-Zabala A, Martin-Garcia E, de Lecea L, Maldonado R, Berrendero F Hypocretins regulate the anxiogenic-like effects of nicotine and induce reinstatement of nicotine-seeking behavior. J. Neurosci., 2010;30(6):2300-10. 2010 [PMID: 20147556] (IHC-Fr, Mouse) IHC-Fr Mouse
Zhao T, Szabo N, Ma J, Luo L, Zhou X, Alvarez-Bolado G Genetic mapping of Foxb1-cell lineage shows migration from caudal diencephalon to telencephalon and lateral hypothalamus. Eur. J. Neurosci., 2008;28(10):1941-55. 2008 [PMID: 19046377] (IHC-P, Mouse) IHC-P Mouse
Kelz MB, Sun Y, Chen J, Cheng Meng Q, Moore JT, Veasey SC, Dixon S, Thornton M, Funato H, Yanagisawa M An essential role for orexins in emergence from general anesthesia. Proc. Natl. Acad. Sci. U.S.A., 2008;105(4):1309-14. 2008 [PMID: 18195361] (IHC-P, Mouse) IHC-P Mouse
Chen L, Thakkar MM, Winston S, Bolortuya Y, Basheer R, McCarley RW REM sleep changes in rats induced by siRNA-mediated orexin knockdown. Eur. J. Neurosci., 2006;24(7):2039-48. 2006 [PMID: 17067300] (IHC-Fr, Rat) IHC-Fr Rat
Show All 11 Publications.

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Biotin BAM763

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Bioinformatics

Gene Symbol HCRT
Uniprot