Rat Oncostatin M/OSM ELISA Kit (Colorimetric)

ELISA: Rat Oncostatin M/OSM ELISA Kit (Colorimetric) [NBP2-68081] - Samples were spiked with high concentrations of Rat Oncostatin M/OSM and diluted with Reference Standard & Sample Diluent to produce samples with values within the range of the assay.

ELISA: Rat Oncostatin M/OSM ELISA Kit (Colorimetric) [NBP2-68081] - Standard Curve Reference

• Reactivity: Rt
• Applications: ELISA
• Suitable Sample Type: Serum, plasma and other biological fluids
• Standard Curve Range: 15.63 - 1000 pg/mL
• Sensitivity: 9.38 pg/mL

Rat Oncostatin M/OSM ELISA Kit (Colorimetric) Summary

• Specificity: This kit recognizes Rat OSM in samples. No significant cross-reactivity or interference between Rat OSM and analogues was observed.
• Standard Curve Range: 15.63 - 1000 pg/mL
• Sensitivity: 9.38 pg/mL
• Assay Type: Sandwich-ELISA
• Inter-Assay: CV% < 5.63%
• Intra-Assay: CV% < 4.76%
• Spike Recovery: 86-108%
• Sample Volume: 100 uL
• Kit Type: ELISA Kit (Colorimetric)
• Gene: OSM

Applications/Dilutions

• Dilutions:
  • ELISA

Packaging, Storage & Formulations

• Storage: Storage of components varies. See protocol for specific instructions.

Alternate Names for Rat Oncostatin M/OSM ELISA Kit (Colorimetric)

• MGC20461
• oncostatin M
• oncostatin-M
• OSM

Background

Oncostatin M is a 252 amino acid protein that is 28 kDa, acts as growth regulator inhibiting the proliferation of a number of tumor cell lines and stimulating the proliferation of AIDS-KS cells; regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells; uses both type I OSM receptor (heterodimers composed of LIPR and IL6ST) and type II OSM receptor (heterodimers composed of OSMR and IL6ST), and is involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. This protein is being studied for its involvement in several diseases and disorders including arterial occlusive disease, peripheral arterial occlusive disease, leukemia, kaposi's sarcoma, abdominal aortic aneurysm, status epilepticus, primary cutaneous amyloidosis, aortic aneurysm, bullous pemphigoid, neonatal jaundice, cutaneous malignant melanoma, plasmacytoma, systemic mastocytosis, mastocytosis, cervical squamous cell carcinoma, systemic lupus erythematosus, allergic rhinitis, squamous cell carcinoma, and lupus erythematosus. The protein has been linked to immune response IL-3 activation and signaling pathway, immune response oncostatin M signaling via JAK-Stat in human cells, development thrombopoetin signaling via JAK-STAT pathway, immune response Oncostatin M signaling via MAPK in human cells, MAPK signaling, endothelin-1 signaling pathway, molecular mechanisms of cancer, antioxidant action of vitamin-C, and Rho Family GTPases pathways where it interacts with IL6ST, TNNT1, LIFR, COL4A4, and COL4A6.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

Publications for Oncostatin M/OSM ELISA Kit (NBP2-68081)(1)

Publication using NBP2-68081

• Negrini K The Role of Oncostatin M in Exercise-Induced Delayed Latency of Breast Cancer Thesis 2023-01-01 (ELISA)

Bioinformatics

• Gene Symbol: OSM