OCIL/CLEC2d Antibody [Alexa Fluor® 647]

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 647

OCIL/CLEC2d Antibody [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant mouse OCIL/CLEC2d
  Ala65-Ser207
  Accession # Q91V08
• Specificity: Detects mouse OCIL/CLEC2d in direct ELISAs and Western blots. In Western blots, approximately 35% cross-reactivity with recombinant mouse OCILRP2 is observed and less than 2% cross-reactivity with recombinant human OCIL is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for OCIL/CLEC2d Antibody [Alexa Fluor® 647]

• CLAXLLT-1
• CLEC2D
• C-type lectin domain family 2 member D
• C-type lectin domain family 2, member D
• C-type lectin related f
• Lectin-like NK cell receptor
• Lectin-like transcript 1
• LLT1
• LLT1Osteoclast inhibitory lectin
• OCIL
• OCILmember D

Background

Mouse OCIL, also known as C-type lectin-related b (Clrb), is a type II transmembrane protein belonging to the natural killer (NK) cell receptor group of the C-type lectin superfamily. It is found on hematopoietic cells, osteoclasts and chondrocytes. OCIL preferentially binds high molecular weight, sulfated glycosaminoglycans and is a ligand for the mouse NK R-PIB/D receptor. OCIL blocks osteoclast differentiation. Engagement of OCIL with NK R-PIB/D on NK cells inhibits NK cell functions. The extracellular domain of mouse OCIL shares 49% and 71% amino acid sequence identity with rat and human OCIL, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.