Nucleoredoxin Antibody

Images

 
Western blot shows lysates of HEK293 human embryonic kidney cell line and HepG2 human hepatocellular carcinoma cell line. PVDF membrane was probed with 1 µg/mL of Human Nucleoredoxin Antigen Affinity-purified ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price

Nucleoredoxin Antibody Summary

Immunogen
E. coli-derived recombinant human NRX
Asn131-Ile435
Accession # Q6DKJ4
Specificity
Detects endogenous human Nucleoredoxin in Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
NXN
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Nucleoredoxin Antibody

  • EC 1.8.1.8
  • NRN
  • NRX
  • NRXFLJ12614
  • nucleoredoxin 1
  • Nucleoredoxin
  • NXN
  • TRG-4

Background

Nucleoredoxin (NRX; also known as NXN and Red-1) is a 51‑55 kDa member of the thioredoxin (TXR) family of proteins. It is widely expressed, and exists in both the nucleus and cytoplasm of cells where it regulates two pathways. In the nucleus, NRX may act as a transcription factor in the Wnt-pathway; a stable (reduced) NRX binds to DVL, thereby blocking downstream Wnt/ beta -catenin signaling. It also binds to PP2A subunits PP2AC and PP2AA, generating an active PP2A complex. Human NRX is 435 amino acids (aa) in length and contains a TXR domain (aa 167‑321) that shows a WCPPC catalytic site, and a substrate recognition PDI-b’ region (aa 312‑427). There are three potential isoform variants. Over amino acids 131‑435, human NRX shares 99% aa identity with mouse NRX.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

AF7548
Species: Hu
Applications: IHC
NBP2-52983
Species: Hu, Mu
Applications: WB, Flow, ICC/IF, IHC, IHC-P
AF4340
Species: Hu, Rt
Applications: WB, IHC
NBP2-24648
Species: Hu, Mu, Rt, Pm
Applications: WB
AF3399
Species: Hu, Mu
Applications: WB, Simple Western
H00055697-B01P
Species: Hu
Applications: WB, ELISA, ICC/IF
NBP2-67471
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
NB100-56566
Species: Hu, Mu, Rt, Po, Bv, Ma
Applications: WB, ChIP, DB, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, In vitro, B/N, CyTOF-ready, Dual ISH-IHC, ELISA(Cap), Flow-CS, Flow-IC, KO
NBP2-38492
Species: Hu
Applications: ICC/IF, IHC, IHC-P
NBP1-31113
Species: Hu, Mu, Rt, Mk
Applications: WB, ICC/IF, IHC, IHC-P
NBP1-90040
Species: Hu
Applications: ICC/IF, IHC, IHC-P
NBP1-89679
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
NBP2-29328
Species: Hu, Mu, Rt, Xp, Ye, Ze
Applications: ELISA
NBP2-67623
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, IP
H00115861-M01
Species: Hu
Applications: WB, ELISA
NBP2-44405
Species: Hu
Applications: Flow, IHC, IHC-P, IF
H00009588-M01
Species: Hu, Bv
Applications: WB, DB, ELISA
NBP2-20619
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P

Publications for Nucleoredoxin Antibody (AF5719) (0)

There are no publications for Nucleoredoxin Antibody (AF5719).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Nucleoredoxin Antibody (AF5719) (0)

There are no reviews for Nucleoredoxin Antibody (AF5719). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for Nucleoredoxin Antibody (AF5719) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Other Available Formats

Additional Nucleoredoxin Products

Bioinformatics Tool for Nucleoredoxin Antibody (AF5719)

Discover related pathways, diseases and genes to Nucleoredoxin Antibody (AF5719). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Nucleoredoxin Antibody (AF5719)

Discover more about diseases related to Nucleoredoxin Antibody (AF5719).
 

Pathways for Nucleoredoxin Antibody (AF5719)

View related products by pathway.

PTMs for Nucleoredoxin Antibody (AF5719)

Learn more about PTMs related to Nucleoredoxin Antibody (AF5719).

Blogs on Nucleoredoxin

There are no specific blogs for Nucleoredoxin, but you can read our latest blog posts.
Recombinant Monoclonal Antibodies

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Nucleoredoxin Antibody and receive a gift card or discount.

Bioinformatics

Gene Symbol NXN
Uniprot
Novus 100% Guarantee