Nucleoredoxin Antibody [Alexa Fluor® 350]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 350

Nucleoredoxin Antibody [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human NRX
  Asn131-Ile435
  Accession # Q6DKJ4
• Specificity: Detects endogenous human Nucleoredoxin in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Nucleoredoxin Antibody [Alexa Fluor® 350]

• EC 1.8.1.8
• NRN
• NRX
• NRXFLJ12614
• nucleoredoxin 1
• Nucleoredoxin
• NXN
• TRG-4

Background

Nucleoredoxin (NRX; also known as NXN and Red-1) is a 51‑55 kDa member of the thioredoxin (TXR) family of proteins. It is widely expressed, and exists in both the nucleus and cytoplasm of cells where it regulates two pathways. In the nucleus, NRX may act as a transcription factor in the Wnt-pathway; a stable (reduced) NRX binds to DVL, thereby blocking downstream Wnt/ beta -catenin signaling. It also binds to PP2A subunits PP2A_C and PP2A_A, generating an active PP2A complex. Human NRX is 435 amino acids (aa) in length and contains a TXR domain (aa 167‑321) that shows a WCPPC catalytic site, and a substrate recognition PDI-b’ region (aa 312‑427). There are three potential isoform variants. Over amino acids 131‑435, human NRX shares 99% aa identity with mouse NRX.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.