NPAS3 Antibody

Images

 
Western Blot: NPAS3 Antibody [NBP1-76785] - SK-N-SH cell lysate with NPAS3 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
Immunocytochemistry/ Immunofluorescence: NPAS3 Antibody [NBP1-76785] - Immunofluorescence of NPAS3 in human brain tissue with NPAS3 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: NPAS3 Antibody [NBP1-76785] - Human brain tissue with NPAS3 antibody at 5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

NPAS3 Antibody Summary

Immunogen
Antibody was raised against a 28 amino acid synthetic peptide from near the amino terminus of human NPAS3. The immunogen is located within amino acids 40 - 90 of NPAS3.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
NPAS3
Purity
Peptide affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5-2 ug/ml
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 5 ug/ml
  • Immunohistochemistry-Paraffin 5 ug/ml
Control Peptide

Reactivity Notes

Expected species cross reactivity based on sequence homology: Bovine (84%), Chicken (80%)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified

Alternate Names for NPAS3 Antibody

  • Basic-helix-loop-helix-PAS protein MOP6
  • BHLHE12
  • bHLHe12FLJ11605
  • Class E basic helix-loop-helix protein 12
  • Member of PAS protein 6
  • MOP6FLJ10003
  • neuronal PAS domain protein 3
  • neuronal PAS domain-containing protein 3
  • Neuronal PAS3
  • PAS domain-containing protein 6
  • PASD6FLJ11138

Background

Neuronal PAS domain protein 3 (NPAS3) is a brain-enriched basic helix-loop-helix PAS domain transcription factor and is broadly expressed in the developing neuroepithelium and has recently found to be disrupted by genetic translocation in a family affected with schizophrenia. It was recently shown to be involved in the regulation of FGF signaling in the dentate gyrus by controlling the expression of the FGF receptor subtype 1 and in turn neurogenesis emanating from this region. NPAS3-null mice were growth-retarded and displayed brain defects that included reduced size of the anterior hippocampus, hypoplasia of the corpus callosum, and enlargement of the ventricles, as well as several behavioral abnormalities. Furthermore, these NPAS3-null mice also exhibited disruptions in several neurosignaling pathways involving glutamate, dopamine, and serotonin. These results demonstrate the essential role played by NPAS3 during structural and functional brain development. At least three isoforms of NPAS3 are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol NPAS3
Uniprot
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