NOS1AP Antibody

Immunohistochemistry: NOS1AP Antibody [NB100-1090] - (5ug/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Immunohistochemistry-Paraffin: NOS1AP Antibody [NB100-1090] - Human Brain

• Reactivity: Hu, Mu, Rt, Bv
• Applications: ELISA, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

NOS1AP Antibody Summary

• Immunogen: Peptide with sequence PSKTKYNLVDDGH-C corresponding to N-Terminus according to NP_001158229.1.
• Specificity: This antibody is expected to recognise both reported isoforms.
• Predicted Species: Mouse (100%), Rat (100%), Bovine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: NOS1AP
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 4 - 6 ug/ml
  • Immunohistochemistry-Paraffin 4 - 6 ug/ml
  • Peptide ELISA Detection limit 1:1000
• Application Notes: IHC-P: Human brain shows localized cytoplasm staining in the neuronal cells.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for NOS1AP Antibody

• 6330408P19Rik
• CAPONMGC138500
• carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein
• C-terminal PDZ ligand of neuronal nitric oxide synthase protein
• KIAA0464C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON)
• ligand of neuronal nitric oxide synthase with carboxyl-terminal PDZ domain
• nitric oxide synthase 1 (neuronal) adaptor protein
• Nitric oxide synthase 1 adaptor protein

Background

NOS1AP encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for NOS1AP Antibody (NB100-1090)(1)

Publication using NB100-1090

• Jaffrey SR, Snowman AM, Eliasson MJ et al. CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. Neuron 1998-01-01 [PMID: 9459447]

Bioinformatics

• Gene Symbol: NOS1AP
• Entrez:
  • 70729(Mouse)
  • 192363(Rat)
• Uniprot:
  • NP_055512.1(Human)