NKG2C/CD159c/KLRC2 Antibody (134522) [Unconjugated]

Images

 
Human peripheral blood lymphocytes were stained with Mouse Anti-Human NCAM‑1/CD56 APC‑conjugated Monoclonal Antibody (Catalog # FAB2408A) and either (A) Mouse Anti-Human NKG2C/CD159c Monoclonal Antibody ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, CyTOF-reported
Clone
134522
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
LYOPH

NKG2C/CD159c/KLRC2 Antibody (134522) [Unconjugated] Summary

Immunogen
BaF3 mouse pro-B cell line transfected with human NKG2C/CD159c and CD94
Specificity
Detects human NKG2C/CD159c. Detects human NKG2C/CD159c as part of the NKG2C/CD94 heterodimer in flow cytometry. No
cross-reactivity with the human NKG2A/CD94 heterodimer or with the human CD94 homodimer is detected.
Details of Functionality
ActivityAssaywCitation not found None
Source
N/A
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
KLRC2
Endotoxin Note
<0.10 EU per 1 μg of the antibody by the LAL method.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 0.25 ug/10^6 cells
  • CyTOF-reported
Reviewed Applications
Read 1 Review rated 4
using
MAB1381 in the following applications:

Publications
Read Publications using
MAB1381 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for NKG2C/CD159c/KLRC2 Antibody (134522) [Unconjugated]

  • CD159 antigen-like family member C
  • CD159c antigen
  • CD159c
  • killer cell lectin-like receptor subfamily C, member 2
  • KLRC2
  • MGC138244
  • NK cell receptor C
  • NKG2-C type II integral membrane protein
  • NKG2C
  • NKG2-C
  • NKG2CNKG2-C-activating NK receptor

Background

NKG2C, also known as hemoglobin scavenger receptor, is a type II transmembrane protein expressed exclusively in monocytes and macrophages. It is a scavenger receptor cysteine-rich superfamily (SRCR-SF) protein that contains nine SRCR motifs in its extracellular region. MAB1381 displays potent agonistic activity and also blocks the binding of the NKG2C/CD94 heterodimer to HLA-E tetramers (1-3).
  1. Alici, E. et al. (2008) Blood 111:3155.
  2. Coupel, S. et al. (2007) Blood 109:2806.
  3. Fausther-Bovendo, H. et al. (2008) AIDS 22:217.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for NKG2C/CD159c/KLRC2 Antibody (MAB1381)(9)

We have publications tested in 2 confirmed species: Human, Marmoset.

We have publications tested in 3 applications: CyTof, Flow, Neut.


Filter By Application
CyTof
(1)
Flow
(6)
Neut
(2)
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Human
(8)
Marmoset
(1)
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Showing Publications 1 - 9 of 9.
Publications using MAB1381 Applications Species
CY Chiu, C Sánchez-Sa, J Bouquet, T Li, S Yagi, M Tamhankar, VL Hodara, LM Parodi, S Somasekar, G Yu, LD Giavedoni, S Tardif, J Patterson Experimental Zika Virus Inoculation in a New World Monkey Model Reproduces Key Features of the Human Infection Sci Rep, 2017;7(1):17126. 2017 [PMID: 29215081] (Flow,, Marmoset) Flow Marmoset
Vassilios Lougaris NFKB1 regulates human NK cell maturation and effector functions Clin. Immunol, 2016;0(0):. 2016 [PMID: 27923702] (Flow,, Human) Flow Human
Dolores Redondo-Pa Adaptive NKG2C+ NK Cell Response and the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients J. Immunol, 2016;0(0):. 2016 [PMID: 27913630] (Flow,, Human) Flow Human
Anton O, Vielkind S, Peterson M, Tagaya Y, Long E NK Cell Proliferation Induced by IL-15 Transpresentation Is Negatively Regulated by Inhibitory Receptors. J Immunol, 2015;195(10):4810-21. 2015 [PMID: 26453750] (Flow,, Human) Flow Human
Horowitz A, Guethlein L, Nemat-Gorgani N, Norman P, Cooley S, Miller J, Parham P Regulation of Adaptive NK Cells and CD8 T Cells by HLA-C Correlates with Allogeneic Hematopoietic Cell Transplantation and with Cytomegalovirus Reactivation. J Immunol, 2015;195(9):4524-36. 2015 [PMID: 26416275] (CyTof,, Human) CyTof Human
Costa-Garcia M, Vera A, Moraru M, Vilches C, Lopez-Botet M, Muntasell A Antibody-mediated response of NKG2Cbright NK cells against human cytomegalovirus. J Immunol, 2015;194(6):2715-24. 2015 [PMID: 25667418] (Flow,, Human) Flow Human
Heatley, Susan L, Pietra, Gabriell, Lin, Jie, Widjaja, Jacqueli, Harpur, Christop, Lester, Sue, Rossjohn, Jamie, Szer, Jeff, Schwarer, Anthony, Bradstock, Kenneth, Bardy, Peter G, Mingari, Maria Cr, Moretta, Lorenzo, Sullivan, Lucy C, Brooks, Andrew G Polymorphism in human cytomegalovirus UL40 impacts on recognition of human leukocyte antigen-E (HLA-E) by natural killer cells. J Biol Chem, 2013;288(12):8679-90. 2013 [PMID: 23335510] (Flow,, Human) Flow Human
Alici E, Sutlu T, Bjorkstrand B, Gilljam M, Stellan B, Nahi H, Quezada HC, Gahrton G, Ljunggren HG, Dilber MS Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components. Blood, 2008;111(6):3155-62. 2008 [PMID: 18192509] (Neut,, Human) Neut Human
Coupel S, Moreau A, Hamidou M, Horejsi V, Soulillou JP, Charreau B Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation. Blood, 2007;109(7):2806-14. 2007 [PMID: 17179229] (Neut,, Human) Neut Human

Review for NKG2C/CD159c/KLRC2 Antibody (MAB1381) (1) 41

Average Rating: 4
(Based on 1 review)
We have 1 review tested in 1 species: Other.

Reviews using MAB1381:
Filter by Applications
Flow
(1)
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Other
(1)
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Images Ratings Applications Species Date Details
 
reviewed by:
Anonymous
Flow Other 02/10/2015
View

Summary

ApplicationFlow Cytometry
Sample TestedSee PMID 24660852
SpeciesOther

Blocking

Blocking DetailsSee PMID 24660852

Details

Detection NotesSee PMID 24660852

Comments

CommentsIndependent review from antibodyresource.com

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Recent Reviews

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Anonymous
02/10/2015
Application: Flow
Species: Other

Bioinformatics

Gene Symbol KLRC2