NKG2C/CD159c/KLRC2 Antibody (134522) [Janelia Fluor® 585]

Product Discontinued

NKG2C/CD159c/KLRC2 Antibody (134522) [Janelia Fluor® 585] Summary

• Immunogen: BaF3 mouse pro-B cell line transfected with human NKG2C/CD159c and CD94
• Specificity: Detects human NKG2C/CD159c. Detects human NKG2C/CD159c as part of the NKG2C/CD94 heterodimer in flow cytometry. No
  cross-reactivity with the human NKG2A/CD94 heterodimer or with the human CD94 homodimer is detected.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: KLRC2

Applications/Dilutions

• Dilutions:
  • CyTOF-reported
  • Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for NKG2C/CD159c/KLRC2 Antibody (134522) [Janelia Fluor® 585]

• CD159 antigen-like family member C
• CD159c antigen
• CD159c
• killer cell lectin-like receptor subfamily C, member 2
• KLRC2
• MGC138244
• NK cell receptor C
• NKG2-C type II integral membrane protein
• NKG2C
• NKG2-C
• NKG2CNKG2-C-activating NK receptor

Background

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The group, designated KLRC (NKG2) are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. KLRC2 alternative splice variants have been described but their full-length nature has not been determined. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: KLRC2