NKCC1/SLC12A2 Antibody (915911) [Alexa Fluor® 532]

• Reactivity: Hu
• Applications: Flow, CyTOF-ready
• Clone: 915911
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 532

NKCC1/SLC12A2 Antibody (915911) [Alexa Fluor® 532] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human NKCC1/SLC12A2
  Met1-Ser1212
  Accession # P55011
• Specificity: Stains NKCC1/SLC12A2 transfectants but not irrelevant transfectants in flow cytometry.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: SLC12A2
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for NKCC1/SLC12A2 Antibody (915911) [Alexa Fluor® 532]

• Basolateral Na-K-Cl symporter
• BSC
• BSC2
• Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
• NKCC1
• NKCC1MGC104233
• SLC12A2
• solute carrier family 12 (sodium/potassium/chloride transporters), member 2
• solute carrier family 12 member 2

Background

Belonging to the SLC12A transporter family, NKCC1 is located on the basolateral membrane of secretory epithelia. Playing an important role in ionic balance and cell volume, NKCC1 is an electrically silent transporter system that mediates sodium, potassium and chloride transport and reabsorption. NKCC1 has interaction with OXSR1, STK39, MAPK14, UBC and RANBP2. Diseases associated with NKCC1 include hearing loss, growth failure, bleeding, torticollis and small intestinal prolapse and Bartter disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SLC12A2