Neurofibromin 1 Antibody - BSA Free

Immunohistochemistry-Paraffin: Neurofibromin 1 Antibody [NBP2-37914] - Staining of human skeletal muscle shows no positivity in myocytes as expected.

Immunohistochemistry-Paraffin: Neurofibromin 1 Antibody [NBP2-37914] - Staining of human kidney shows strong granular cytoplasmic positivity in cells in tubules.

Immunohistochemistry-Paraffin: Neurofibromin 1 Antibody [NBP2-37914] - Staining of human placenta shows moderate to strong granular cytoplasmic positivity in trophoblastic cells.

Immunohistochemistry-Paraffin: Neurofibromin 1 Antibody [NBP2-37914] - Staining of human testis shows strong granular positivity in cytoplasm in Leydig cells.

• Reactivity: Hu, Mu, Rt
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

Neurofibromin 1 Antibody - BSA Free Summary

• Immunogen: This antibody was developed against a recombinant protein corresponding to amino acids: ALLVLRQLDSIDLWNPDAPGETF
• Predicted Species: Mouse (91%), Rat (91%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: NF1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200 - 1:500
  • Immunohistochemistry-Paraffin 1:200 - 1:500
• Application Notes: For IHC-Paraffin, HIER pH 6 retrieval is recommended.
• Control Peptide:

  Neurofibromin 1 Protein (NBP2-37914PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for Neurofibromin 1 Antibody - BSA Free

• DKFZp686J1293
• FLJ21220
• Neurofibromatosis-related protein NF-1
• neurofibromin 1
• neurofibromin
• NFNS
• VRNF
• WSS

Background

Neurofibromin 1 (NF1) is a suspected negative regulator of the ras signal transduction pathway. Neurofibromin is known to regulate the GTPase HRAS, causing the hydrolyzation and inactivation of GTP. Defects in NF1 lead to Neurofibromatosis disease, Recklinghausen disease or Watson disease. Neurofibromin has not been purified, therefore, most of the information regarding this protein has been deduced from homology analysis of its gene sequence.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NF1
• Uniprot:
  • P21359(Human)