Nectin-2/CD112 Antibody (2A6-2C1)

Western Blot: Nectin-2/CD112 Antibody (2A6-2C1) [H00005819-M01] - Analysis of PVRL2 expression in transfected 293T cell line by PVRL2 monoclonal antibody (M01), clone 2A6-2C1.Lane 1: PVRL2 transfected lysate (Predicted MW: 51.4 KDa).Lane 2: Non-transfected lysate.

Immunoprecipitation: Nectin-2/CD112 Antibody (2A6-2C1) [H00005819-M01] - Analysis of PVRL2 transfected lysate using anti-PVRL2 monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with PVRL2 MaxPab rabbit polyclonal antibody.

Sandwich ELISA: Nectin-2/CD112 Antibody (2A6-2C1) [H00005819-M01] - Detection limit for recombinant GST tagged PVRL2 is 1 ng/ml as a capture antibody.

Product Discontinued

Nectin-2/CD112 Antibody (2A6-2C1) Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: PVRL2 (AAH03091, 1 a.a. ~ 479 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MARAAALLPSRSPPTPLLWPLLLLLFLETGAQDVRVQVLPEVRGQLGGTVELPCHLLPPVPGLYISLVTWQRPDAPANHQNVAAFHPKMGPSFPSPKPGSERLSFVSAKQSTGQDTEAELQDATLALHGLTVEDEGNYTCEFATFPKGSVRGMTWLRVIAKPKNQAEAQKVTFSQDPTTVALCISKEGRPPARISWLSSLDWEAKETQVSGTLAGTVTVTSRFTLVPSGRADGVTVTCKVEHESFEEPALIPVTLSVRYPPEVSISGYDDNWYLGRTDATLSCDVRSNPEPTGYDWSTTSGTFPTSAVAQGSQLVIHAVDSLFNTTFVCTVTNAVGMGRAEQVIFVRETPRASPRDVGPLVWGAVGGTLLVLLLLAGGSLAFILLRVRRRRKSPGGAGGGASGDGGFYDPKAQVLGNGDPVFWTPVVPGPMEPDGKDEEEEEEEEKAEKGLMLPPPPALEDDMESQLDGSLISRRAVYV
• Specificity: PVRL2 - poliovirus receptor-related 2 (herpesvirus entry mediator B)
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: NECTIN2
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunoprecipitation
  • Sandwich ELISA
  • Western Blot 1:500
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Nectin-2/CD112 Antibody (2A6-2C1)

• CD112 antigen
• CD112
• Herpes virus entry mediator B
• Herpesvirus entry mediator B
• herpesvirus entry protein B
• HVEB
• HVEBpoliovirus receptor-like 2
• MPH
• nectin 2
• Nectin2
• Nectin-2
• poliovirus receptor-related 2 (herpesvirus entry mediator B)
• poliovirus receptor-related protein 2
• PRR2
• PRR2nectin-2
• PVRL2
• PVRR2poliovirus receptor related 2

Background

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: NECTIN2
• Entrez:
  • 5819(Human)
• OMIM:
  • 600798(Human)
• Uniprot:
  • AAH03091(Human)