MuRF1/TRIM63 Antibody [Alexa Fluor® 647]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 647

MuRF1/TRIM63 Antibody [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human MuRF1/TRIM63
  Met1-Gly325
  Accession # Q969Q1
• Specificity: Detects human, mouse, and rat MuRF1/TRIM63 in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MuRF1/TRIM63 Antibody [Alexa Fluor® 647]

• EC 6.3.2.-
• IRF
• IRFMURF2
• Iris RING finger protein
• MuRF1
• MuRF-1
• muscle specific ring finger protein 2
• Muscle-specific RING finger protein 1
• RING finger protein 28FLJ32380
• RNF28
• RNF28E3 ubiquitin-protein ligase TRIM63
• SMRZ
• SMRZMURF-1
• Striated muscle RING zinc finger protein
• TRIM63
• tripartite motif containing 63
• tripartite motif-containing 63
• Tripartite motif-containing protein 63

Background

TRIM63 (Tripartite motif-containing protein 63; also MURF-1, SMRZ and RING finger protein 28) is a 41 kDa member of the RING finger-B-box-coiled-coil family of proteins. It is a striated muscle protein that is found in both cytoplasm and nucleus. TRIM63 has multiple finctions, among which are the inhibition of PKC epsilon -mediated cardiomyocyte hypertrophy and the maintenance of skeletal muscle M-line integrity. Human TRIM63 is 353 amino acids (aa) in length. It contains one RING finger domain (aa 23‑82), a B-Box type zinc-finger region (aa 117‑159), a coiled-coil region (aa 207‑269) and a C-terminal COS domain. Isoforms of TRIM63 show one potential alternate start site at Met14, a deletion of aa 105‑132 and a 21 aa substitution for aa 326‑353. Over aa 1‑325, human TRIM63 exhibits 93% aa identity with mouse TRIM63.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.