MuRF1/TRIM63 Products

Description

MURF1 encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is localized to the Z-line and M-line lattices of myofibrils, where titin's N-terminal and C-terminal regions respectively bind to the sarcomere. In vitro binding studies have shown that this protein also binds directly to titin near the region of titin containing kinase activity. Another member of this protein family binds to microtubules. Since these family members can form heterodimers, this suggests that these proteins may serve as a link between titin kinase and microtubule-dependent signal pathways in muscle.

Bioinformatics

Entrez	84676 Human
Uniprot	NP_115977 Human NP_115977.2 Human Q969Q1 Human
Product By Gene ID	84676
Alternate Names	EC 6.3.2.- IRFMURF2 Iris RING finger protein MuRF1 MURF1 MuRF-1 muscle specific ring finger protein 2 Muscle-specific RING finger protein 1 RING finger protein 28FLJ32380 RNF28E3 ubiquitin-protein ligase TRIM63 SMRZMURF-1 Striated muscle RING zinc finger protein tripartite motif containing 63 tripartite motif-containing 63 Tripartite motif-containing protein 63

Research Areas for MuRF1/TRIM63

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Zinc Finger