MTF2 Antibody

Images

 
MTF2 was detected in immersion fixed paraffin-embedded sections of human liver using Sheep Anti-Human MTF2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6846) at 3 µg/mL overnight at 4 °C. Before ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC
Clonality
Polyclonal
Host
Sheep
Conjugate
Unconjugated
Concentration
LYOPH

Order Details

View Available Formulations
Catalog# & Formulation Size Price

MTF2 Antibody Summary

Immunogen
E. coli-derived recombinant human MTF2
Asn356-Ser554
Accession # Q9Y483
Specificity
Detects human MTF2 in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
MTF2
Purity
Immunogen affinity purified
Purity Statement
Antigen Affinity-purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 5-15 ug/mL

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Concentration
LYOPH
Purity
Immunogen affinity purified
Reconstitution Instructions
Sterile PBS to a final concentration of 0.2 mg/mL.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MTF2 Antibody

  • M96
  • metal response element binding transcription factor 2
  • MTF2
  • PCI2
  • PCL2

Background

MTF2 (Metal-response element-binding transcription factor 2; also M96, ZiRF1 and PCL2) is a 67 kDa member of the polycomb group of proteins. It appears to participate in the activities of at least two complexes, PRC1 (Polycomb repressive complex 1) and PRC2. In general, the PRC complexes are repressive. In stem cells, MTF2/PRC2 inhibits expression of pluripotency factors such as KLF4 and Tbx3, likely by recruiting the full PRC2 complex to target gene promoters. And during AP specification of the axis, MTF2, as part of both a PRC1 and PRC2 complex, blocks Hox gene expression. Human MTF2 is 593 amino acids (aa) in length. It contains one Tudor domain (aa 40-91), two PHD-type Zn-finger regions (aa 102-157 and 201-255) and three utilized phosphorylation sites at Ser24, 27 and 488. There are multiple potential splice variants. One is 60 kDa in size and shows a deletion of aa 331-387, while a second is 55 kDa in size and possesses an alternative start site at Met103. A third contains a combination of the above, a fourth possesses a 34 aa substitution for aa 1-307, and a fifth utilizes an alternative start site at Met332. Over aa 356-554, human MTF2 shares 94% aa identity with mouse MTF2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for MTF2 Antibody (AF6846) (0)

There are no publications for MTF2 Antibody (AF6846).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for MTF2 Antibody (AF6846) (0)

There are no reviews for MTF2 Antibody (AF6846). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

FAQs for MTF2 Antibody (AF6846) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional MTF2 Products

Blogs on MTF2.

Identifying JARID2 in Embryo Development
The jumonji (JMJ) gene, obtained by a gene trap strategy, is essential for embryogenesis and is suggested to play important roles in cell growth during development. The amino acid sequence of the JMJ protein includes a nuclear localization signal and ...  Read full blog post.

mFluor Violet Conjugated Antibodies

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our MTF2 Antibody and receive a gift card or discount.

Bioinformatics

Gene Symbol MTF2
Uniprot