MP1/MAP2K1IP1 Antibody (448406) [Biotin]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: 448406
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Biotin

MP1/MAP2K1IP1 Antibody (448406) [Biotin] Summary

• Immunogen: E. coli-derived recombinant human MP1
  Ala2-Ser124
  Accession # Q9UHA4
• Specificity: Detects human, mouse, and rat MP1 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: LAMTOR3
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Alternate Names for MP1/MAP2K1IP1 Antibody (448406) [Biotin]

• LAMTOR3
• Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3
• late endosomal/lysosomal adaptor, MAPK and MTOR activator 3
• MAP2K1IP1
• Mapbp
• MAPK scaffold protein 1
• MAPKSP1
• MEK binding partner 1
• MEK partner 1
• MEK-binding partner 1
• mitogen-activated protein kinase kinase 1 interacting protein 1
• Mitogen-activated protein kinase kinase 1-interacting protein 1
• Mitogen-activated protein kinase scaffold protein 1
• MP1
• PRO0633
• Ragulator3

Background

The function of MAP2K1IP1/MAPKSP1 (MP1;MEK partner-1) a 14kDa scaffold protein, is to bind specifically to MEK1 and ERK1 and bring them in close proximity in order to facilitate their activation. Localized to the late endosome, MAP2K1IP1 also interacts with an adaptor protein p14. While the interaction between MAPKSP1-ERK1 can take place in the absence of the adaptor protein p14, it is strengthened in the presence of p14. Additionally, it has been suggested that the binding of MAP2K1IP1/MAPKSP1 to MEK1 resides in a proline-rich sequence (residue 270-307) of MEK1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: LAMTOR3