MP1/MAP2K1IP1 Antibody (448406) [Alexa Fluor™ Plus 647]

• Clone: 448406
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

MP1/MAP2K1IP1 Antibody (448406) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human, mouse, and rat MP1 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

MP1 (MEK Partner 1), gene name LAMTOR3 (late endosomal/lysosomal adaptor and MAPK and MTOR activator 3), was initially identified as a scaffold protein that tethers MEK1 and ERK1 to facilitate their activation. MP1 and other MAPK scaffolds promote phosphorylation efficiency and specificity, localize their bound pathway components to particular subcellular sites, and serve as nodes of signal integration for regulation of MAPK pathways by other signaling events. With the assistance of adaptor protein p14, the bound MP1 complex localizes to late endosomes and is thought to regulate endosomal traffic and cellular proliferation during tissue homeostasis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.