Mouse TIMP-1 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse TIMP-1 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Timp1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse TIMP-1 DuoSet ELISA, 15 Plate

• CLGI
• Collagenase inhibitor
• collagenase inhibitor)
• EPATIMP-1
• EPO
• erythroid potentiating activity
• Erythroid-potentiating activity
• Fibroblast collagenase inhibitor
• FLJ90373
• HCI
• metalloproteinase inhibitor 1
• TIMP metallopeptidase inhibitor 1
• TIMP1
• TIMP-1
• TIMPtissue inhibitor of metalloproteinase 1 (erythroid potentiating activity
• Tissue inhibitor of metalloproteinases 1

Background

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

Publications for TIMP-1 (DY980)(11)

Publications using DY980

• Sutter, PA;Willis, CM;Menoret, A;Nicaise, AM;Sacino, A;Sikkema, AH;Jellison, ER;Win, KK;Han, DK;Church, W;Baron, W;Vella, AT;Crocker, SJ; Astrocytic TIMP-1 regulates production of Anastellin, an inhibitor of oligodendrocyte differentiation and FTY720 responses Proceedings of the National Academy of Sciences of the United States of America 2024-01-30 [PMID: 38266047] (Mouse, Transgenic Mouse)
• MC Morrison, E Gart, WV Duyvenvoor, J Snabel, MJ Nielsen, DJ Leeming, A Menke, R Kleemann Heat-Inactivated Akkermansia muciniphila Improves Gut Permeability but Does Not Prevent Development of Non-Alcoholic Steatohepatitis in Diet-Induced Obese Ldlr-/-.Leiden Mice International Journal of Molecular Sciences, 2022-02-19;23(4):. 2022-02-19 [PMID: 35216439] (Mouse)
• Chris D. Hermann, Benjamin Schoeps, Celina Eckfeld, Enkhtsetseg Munkhbaatar, Lukas Kniep, Olga Prokopchuk et al. TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer Journal of Experimental Medicine 2021-11-01 [PMID: 34533565] (Mouse)
• CL Huang, LL Xiao, M Xu, J Li, SF Li, CS Zhu, YL Lin, R He, X Li Chemerin deficiency regulates adipogenesis is depot different through TIMP1 Genes & diseases, 2020-04-09;8(5):698-708. 2020-04-09 [PMID: 34291141] (Mouse)
• B Burger, CMC Kühl, T Candreva, RDS Cardoso, JR Silva, BG Castelucci, SR Consonni, HL Fisk, PC Calder, MAR Vinolo, HG Rodrigues Oral administration of EPA-rich oil impairs collagen reorganization due to elevated production of IL-10 during skin wound healing in mice Sci Rep, 2019-06-24;9(1):9119. 2019-06-24 [PMID: 31235718] (Mouse)
• J Vandooren, W Swinnen, E Ugarte-Ber, L Boon, D Dorst, E Martens, G Opdenakker Endotoxemia shifts neutrophils with TIMP-free gelatinase B/ MMP-9 from bone marrow to periphery and induces systematic upregulation of TIMP-1 Haematologica, 2017-08-03;0(0):. 2017-08-03 [PMID: 28775117] (Mouse)
• Weber S, Wetzel S, Prox J, Lehmann T, Schneppenheim J, Donners M, Saftig P Regulation of adult hematopoiesis by the a disintegrin and metalloproteinase 10 (ADAM10). Biochem Biophys Res Commun, 2013-11-15;442(3):234-41. 2013-11-15 [PMID: 24239882] (Mouse)
• Koscso B, Csoka B, Kokai E, Nemeth Z, Pacher P, Virag L, Leibovich S, Hasko G Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages. J Leukoc Biol, 2013-08-06;94(6):1309-15. 2013-08-06 [PMID: 23922379] (Mouse)
• Pitteri SJ, Kelly-Spratt KS, Gurley KE Tumor microenvironment-derived proteins dominate the plasma proteome response during breast cancer induction and progression. Cancer Res., 2011-06-08;71(15):5090-100. 2011-06-08 [PMID: 21653680] (Mouse)
• Kang S, Park EJ, Joe Y, Seo E, Park MK, Seo SY, Chung HY, Yoo YH, Kim DK, Lee HJ Systemic delivery of TNF-related apoptosis-inducing ligand (TRAIL) elevates levels of tissue inhibitor of metalloproteinase-1 (TIMP-1) and prevents type 1 diabetes in nonobese diabetic mice. Endocrinology, 2010-11-03;151(12):5638-46. 2010-11-03 [PMID: 21047948] (Mouse)
• Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J. Clin. Invest., 2007-12-01;117(12):3786-99. 2007-12-01 [PMID: 17992263] (Mouse)

Bioinformatics

• Gene Symbol: Timp1