Mouse Serpin E1/PAI-1 DuoSet ELISA, 5 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse Serpin E1/PAI-1 DuoSet ELISA, 5 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Serpine1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse Serpin E1/PAI-1 DuoSet ELISA, 5 Plate

• Endothelial plasminogen activator inhibitor
• Nexin
• PAI1
• PAI-1
• PAI1PAI-1
• PAISerpin E1
• PLANH1
• PLANH1plasminogen activator inhibitor 1
• serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogenactivator inhibitor type 1), member 1
• Serpin E1
• serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitortype 1), member 1

Background

The human serpin superfamily consists of at least 35 members that target not only serine proteases, but also selected cysteine proteases and non-protease proteins. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. As protease inhibitors, serpins have an array of functions including regulating blood clotting, the complement pathway, extracellular matrix remodeling, and cell motility. They are also involved in activities that extend beyond their ability to inhibit proteases. For instance, they may also regulate blood pressure, angiogenesis, or act as storage/transport proteins.

Publications for Serpin E1/PAI-1 (DY3828-05)(7)

Publications using DY3828-05

• Puspitasari, YM;Ministrini, S;Han, J;Karch, C;Prisco, F;Liberale, L;Bengs, S;Akhmedov, A;Montecucco, F;Beer, JH;Lüscher, TF;Bongiovanni, D;Camici, GG; Hutchinson-Gilford progeria syndrome mice display accelerated arterial thrombus formation and increased platelet reactivity Thrombosis research 2024-07-18 [PMID: 39032390] (Transgenic Mouse)
• Brandt, A;Kromm, F;Hernández-Arriaga, A;Martínez Sánchez, I;Bozkir, HÖ;Staltner, R;Baumann, A;Camarinha-Silva, A;Heijtz, RD;Bergheim, I; Cognitive Alterations in Old Mice Are Associated with Intestinal Barrier Dysfunction and Induced Toll-like Receptor 2 and 4 Signaling in Different Brain Regions Cells 2023-08-27 [PMID: 37681885] (Mouse)
• Li, L;Geng, J;Yu, W;Zhou, F;Zheng, Z;Fu, K;Kong, J;Feng, X; Inhibition of PPAR? by BZ26, a GW9662 derivate, attenuated obesity-related breast cancer progression by inhibiting the reprogramming of mature adipocytes into to cancer associate adipocyte-like cells Frontiers in pharmacology 2023-08-15 [PMID: 37649895] (Mouse)
• YH Su, YZ Wu, DK Ann, JL Chen, CY Kuo Obesity promotes radioresistance through SERPINE1-mediated aggressiveness and DNA repair of triple-negative breast cancer Cell Death & Disease, 2023-01-21;14(1):53. 2023-01-21 [PMID: 36681663] (Mouse)
• Y Sun, F Ye, D Li, H Yang, T Xu, X Zhong, Y Lu, H Zhou, J Pan Fibroblast growth factor 2 (FGF2) ameliorates the coagulation abnormalities in sepsis Toxicology and Applied Pharmacology, 2023-01-06;460(0):116364. 2023-01-06 [PMID: 36621722] (Mouse)
• WF Fang, YM Chen, CY Lin, HL Huang, H Yeh, YT Chang, KT Huang, MC Lin Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression J Inflamm (Lond), 2018-01-10;15(0):3. 2018-01-10 [PMID: 29344006] (Mouse)
• G Hoppe, S Yoon, B Gopalan, AR Savage, R Brown, K Case, A Vasanji, ER Chan, RB Silver, JE Sears Comparative systems pharmacology of HIF stabilization in the prevention of retinopathy of prematurity Proc Natl Acad Sci USA, 2016-04-18;0(0):. 2016-04-18 [PMID: 27091985] (Mouse)

FAQs for Serpin E1/PAI-1 (DY3828-05). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: Serpine1