Mouse IL-12 p70 DuoSet ELISA, 15 Plate

• Reactivity: Mu
• Applications: ELISA
• Conjugate: Biotin

Mouse IL-12 p70 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: Il12a

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Mouse IL-12 p70 DuoSet ELISA, 15 Plate

• CLMF p35
• Cytotoxic lymphocyte maturation factor 35 kDa subunit
• IL12 p70
• IL-12 p70
• IL-12 subunit p35
• IL-12, subunit p35
• interleukin 12, p35
• interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocytematuration factor 1, p35)
• interleukin-12 alpha chain
• interleukin-12 subunit alpha
• natural killer cell stimulatory factor 1, 35 kD subunit
• NF cell stimulatory factor chain 1
• NK cell stimulatory factor chain 1
• NKSF1
• p35

Background

Interleukin 12 (IL-12), also known as natural killer cell stimulatory factor (NKSF) or cytotoxic lymphocyte maturation factor (CLMF), is a heterodimeric pleiotropic cytokine made up of a 40 kDa (p40) subunit and a 35 kDa (p35) subunit. The IL-12 p40 subunit is shared by IL-23, another heterodimeric cytokine that has biological activities similar to, as well as distinct from, IL-12. IL-12 is produced by macrophages and B cells and has been shown to have multiple effects on T cells and natural killer (NK) cells. While mouse IL-12 is active on both human and mouse cells, human IL-12 is not active on mouse cells.

Publications for IL-12 p70/IL-12A (DY419)(88)

Publications using DY419

• Jellmayer, JA;Deus, AF;Curti Gonçalves, MR;Souza Ferreira, L;Manente, FA;Pinho Caetano, LS;Piccineli, FL;Zamberço Dos Reis Genari, T;Saçaki, BDC;Pavicic Catalan de Oliveira Campos, T;Portuondo, DL;Batista-Duharte, A;Carlos, IZ; Dendritic Cell-Based Therapeutic Immunization Induces Th1/Th17 Responses and Reduces Fungal Burden in Experimental Sporotrichosis Microorganisms 2025-10-14 [PMID: 41156812] (Mouse)
• Previtalli-Silva, H;Hardoim, DJ;Banaggia, RL;Moragas-Tellis, CJ;Chagas, MDSDS;Behrens, MD;Dias-Silva, TS;Calabrese, KDS;Cardoso, FO; Antioxidant and anti-inflammatory activity of Euterpe oleracea Mart. (Açaí) seed bioproducts Heliyon 2024-12-15 [PMID: 39669170] (Mouse)
• Hering, M;Madi, A;Sandhoff, R;Ma, S;Wu, J;Mieg, A;Richter, K;Mohr, K;Knabe, N;Stichling, D;Poschet, G;Bestvater, F;Frank, L;Utikal, J;Umansky, V;Cui, G; Sphinganine recruits TLR4 adaptors in macrophages and promotes inflammation in murine models of sepsis and melanoma Nature communications 2024-07-18 [PMID: 39025856] (Mouse)
• Zhou, B;Elean, M;Arce, L;Fukuyama, K;Tomotsune, K;Dentice Maidana, S;Saha, S;Namai, F;Nishiyama, K;Vizoso-Pinto, MG;Villena, J;Kitazawa, H; The Mucus-Binding Factor Mediates Lacticaseibacillus rhamnosus CRL1505 Adhesion but Not Immunomodulation in the Respiratory Tract Microorganisms 2024-06-16 [PMID: 38930591] (Mouse)
• Elean, M;Raya Tonetti, F;Fukuyama, K;Arellano-Arriagada, L;Namai, F;Suda, Y;Gobbato, N;Nishiyama, K;Villena, J;Kitazawa, H; Immunobiotic Ligilactobacillus salivarius FFIG58 Confers Long-Term Protection against Streptococcus pneumoniae International journal of molecular sciences 2023-10-30 [PMID: 37958756] (Mouse)
• Heinzl, GC;Eriksen, DB;Johnsen, PR;Scarafoni, A;Frøkiær, H; Protein Concentration Affects the Food Allergen ?-Conglutin Uptake and Bacteria-Induced Cytokine Production in Dendritic Cells Biomolecules 2023-10-16 [PMID: 37892213] (Mouse)
• Maggi, L;Camelo, GMA;Rocha, IC;Pereira Alves, W;Moreira, JMP;Almeida Pereira, T;Tafuri, WL;Rabelo, ÉML;Correa, A;Ecco, R;Negrão-Corrêa, DA; Role of the IL-33/ST2 Activation Pathway in the Development of the Hepatic Fibrosis Induced by Schistosoma mansoni Granulomas in Mice International journal of molecular sciences 2023-06-16 [PMID: 37373379] (Mouse)
• P Schädel, A Czapka, N Gebert, ID Jacobsen, A Ori, O Werz Metabololipidomic and proteomic profiling reveals aberrant macrophage activation and interrelated immunomodulatory mediator release during aging Aging Cell, 2023-04-26;0(0):e13856. 2023-04-26 [PMID: 37101405] (Mouse)
• PR Johnsen, C Pinna, L Mattio, MB Strube, M Di Nunzio, S Iametti, S Dallavalle, A Pinto, H Frøkiær Investigation of the Effects of Monomeric and Dimeric Stilbenoids on Bacteria-Induced Cytokines and LPS-Induced ROS Formation in Bone Marrow-Derived Dendritic Cells International Journal of Molecular Sciences, 2023-02-01;24(3):. 2023-02-01 [PMID: 36769058] (Mouse)
• Y Lin, X Cui, Q Cao, R Bi, Y Liu, D Jing, C Yue, Q Zhao, Y Wang, S Liu, Y Su, K Formoso, S Susperregu, L Birnbaumer, M Freichel, Y Yang, L You, X Gao TRPC absence induces pro-inflammatory macrophages and gut microbe disorder, sensitizing mice to colitis International immunopharmacology, 2022-12-31;115(0):109655. 2022-12-31 [PMID: 36592529] (Mouse)
• M Tomokiyo, FR Tonetti, H Yamamuro, R Shibata, K Fukuyama, N Gobbato, L Albarracin, MSR Rajoka, AKMH Kober, W Ikeda-Ohts, J Villena, H Kitazawa Modulation of Alveolar Macrophages by Postimmunobiotics: Impact on TLR3-Mediated Antiviral Respiratory Immunity Cells, 2022-09-25;11(19):. 2022-09-25 [PMID: 36230948] (Mouse)
• Y Ni, GH Wu, JJ Cai, R Zhang, Y Zheng, JQ Liu, XH Yang, X Yang, Y Shen, JM Lai, XM Ye, SJ Mo Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy of high-dose ascorbate mediated by NRF2 transactivation International journal of biological sciences, 2022-08-08;18(13):5168-5184. 2022-08-08 [PMID: 35982894] (Mouse)
• J Hu, Y Zhang, S Yi, C Wang, X Huang, S Pan, J Yang, G Yuan, S Tan, H Li Lithocholic acid inhibits dendritic cell activation by reducing intracellular glutathione via TGR5 signaling International journal of biological sciences, 2022-07-11;18(11):4545-4559. 2022-07-11 [PMID: 35864954] (Mouse)
• F Scopelliti, L Mercurio, C Cattani, V Dimartino, C Albanesi, G Costanzo, C Mirisola, S Madonna, A Cavani The phosphoinositide-3-kinase (PI3K)-delta inhibitor seletalisib impairs monocyte-derived dendritic cells maturation, APC function, and promotes their migration to CCR7 and CXCR4 ligands Journal of leukocyte biology, 2022-02-24;0(0):. 2022-02-24 [PMID: 35199885] (Mouse)
• J Tomala, P Weberova, B Tomalova, Z Jiraskova, L Sivak, J Kovarova, M Kovar IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-gamma production by CD25+Foxp3- T cells Elife, 2021-12-21;10(0):. 2021-12-21 [PMID: 34932467] (Mouse)
• LAD Queiroz, JB Assis, JPT Guimarães, ESA Sousa, AC Milhomem, KKS Sunahara, A Sá-Nunes, JO Martins Endangered Lymphocytes: The Effects of Alloxan and Streptozotocin on Immune Cells in Type 1 Induced Diabetes Mediators of Inflammation, 2021-10-19;2021(0):9940009. 2021-10-19 [PMID: 34712101] (Mouse)
• DE Jæhger, ML Hübbe, MK Kræmer, G Clergeaud, AV Olsen, C Stavnsbjer, MN Wiinholt, A Kjær, JR Henriksen, AE Hansen, TL Andresen Enhancing adoptive CD8 T cell therapy by systemic delivery of tumor associated antigens Scientific Reports, 2021-10-05;11(1):19794. 2021-10-05 [PMID: 34611284] (Mouse)
• J Hu, C Wang, X Huang, S Yi, S Pan, Y Zhang, G Yuan, Q Cao, X Ye, H Li Gut microbiota-mediated secondary bile acids regulate dendritic cells to attenuate autoimmune uveitis through TGR5 signaling Cell Reports, 2021-09-21;36(12):109726. 2021-09-21 [PMID: 34551302] (Mouse)
• CF Ellefsen, CW Wold, AL Wilkins, F Rise, ABC Samuelsen Water-soluble polysaccharides from Pleurotus eryngii fruiting bodies, their activity and affinity for Toll-like receptor 2 and dectin-1 Carbohydrate polymers, 2021-03-26;264(0):117991. 2021-03-26 [PMID: 33910729] (Mouse)
• D Arsenijevi, B Stojanovic, J Milovanovi, A Arsenijevi, M Simic, M Pergal, I Kodranov, O Cvetkovic, D Vojvodic, E Ristanovic, D Manojlovic, M Milovanovi, N Arsenijevi Hepatoprotective Effect of Mixture of Dipropyl Polysulfides in Concanavalin A-Induced Hepatitis Nutrients, 2021-03-22;13(3):. 2021-03-22 [PMID: 33809904] (Mouse)
• M Grancieri, HSD Martino, E Gonzalez d Protein Digests and Pure Peptides from Chia Seed Prevented Adipogenesis and Inflammation by Inhibiting PPAR&gamma and NF-&kappaB Pathways in 3T3L-1 Adipocytes Nutrients, 2021-01-08;13(1):. 2021-01-08 [PMID: 33430086] (Mouse)
• S Saito, N Kakizaki, A Okuno, T Maekawa, NM Tsuji Lactococcus lactis subsp. Cremoris C60 restores T Cell Population in Small Intestinal Lamina Propria in Aged Interleukin-18 Deficient Mice Nutrients, 2020-10-27;12(11):. 2020-10-27 [PMID: 33121026] (Mouse)
• J Shin, OK Kim, S Kim, D Bae, J Lee, J Park, W Jun Immunomodulatory Effect of a Salvia plebeia R. Aqueous Extract in Forced Swimming Exercise-induced Mice Nutrients, 2020-07-28;12(8):. 2020-07-28 [PMID: 32731626] (Mouse)
• P Clua, M Tomokiyo, F Raya Tonet, MA Islam, V García Cas, G Marcial, S Salva, S Alvarez, H Takahashi, S Kurata, H Kitazawa, J Villena The Role of Alveolar Macrophages in the Improved Protection against Respiratory Syncytial Virus and Pneumococcal Superinfection Induced by the Peptidoglycan of Lactobacillus rhamnosus CRL1505 Cells, 2020-07-09;9(7):. 2020-07-09 [PMID: 32660087] (Mouse)
• AI Yu, L Zhao, KA Eaton, S Ho, J Chen, S Poe, J Becker, A Gonzalez, D McKinstry, M Hasso, J Mendoza-Ca, J Whitfield, C Koumpouras, PD Schloss, EC Martens, GY Chen Gut Microbiota Modulate CD8�T Cell Responses to Influence Colitis-Associated Tumorigenesis Cell Rep, 2020-04-07;31(1):107471. 2020-04-07 [PMID: 32268087] (Mouse)
• A Famà, A Midiri, G Mancuso, C Biondo, G Lentini, R Galbo, MM Giardina, GV De Gaetano, L Romeo, G Teti, C Beninati Nucleic Acid-Sensing Toll-Like Receptors Play a Dominant Role in Innate Immune Recognition of Pneumococci MBio, 2020-03-24;11(2):. 2020-03-24 [PMID: 32209688] (Mouse)
• OV Masalova, EI Lesnova, RR Klimova, ED Momotyuk, VV Kozlov, AM Ivanova, OV Payushina, NN Butorina, NF Zakirova, AN Narovlyans, AV Pronin, AV Ivanov, AA Kushch Genetically Modified Mouse Mesenchymal Stem Cells Expressing Non-Structural Proteins of Hepatitis C Virus Induce Effective Immune Response Vaccines (Basel), 2020-02-02;8(1):. 2020-02-02 [PMID: 32024236] (Mouse)
• Y Song, HY Jeong, JK Lee, YS Choi, DO Kim, D Jang, CS Park, S Maeng, H Kang Enzyme Treatment Alters the Anti-Inflammatory Activity of the Water Extract of Wheat Germ In Vitro and In Vivo Nutrients, 2019-10-16;11(10):. 2019-10-16 [PMID: 31623257] (Mouse)
• PM Thwe, DI Fritz, JP Snyder, PR Smith, KD Curtis, A O'Donnell, NA Galasso, LA Sepaniac, BJ Adamik, LR Hoyt, PD Rodriguez, TC Hogan, AF Schmidt, ME Poynter, E Amiel Syk-dependent glycolytic reprogramming in dendritic cells regulates IL-1 β production to β-glucan ligands in a TLR-independent manner J. Leukoc. Biol., 2019-09-11;0(0):. 2019-09-11 [PMID: 31509298] (Mouse)
• F Sato-Kanek, X Wang, S Yao, T Hosoya, FS Lao, K Messer, M Pu, NM Shukla, HB Cottam, M Chan, DA Carson, M Corr, T Hayashi Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy Biomed Res Int, 2018-10-10;2018(0):8091283. 2018-10-10 [PMID: 30406141] (Mouse)
• Y Fujita, A Khateb, Y Li, R Tinoco, T Zhang, H Bar-Yoseph, MA Tam, Y Chowers, E Sabo, S Gerassy-Va, E Starosvets, B James, K Brown, SS Shen-Orr, LM Bradley, PA Tessier, ZA Ronai Regulation of S100A8 Stability by RNF5 in Intestinal Epithelial Cells Determines Intestinal Inflammation and Severity of Colitis Cell Rep, 2018-09-18;24(12):3296-3311.e6. 2018-09-18 [PMID: 30232010] (Mouse)
• B Chang, B Koo, H Lee, JS Oh, S Kim Activation of macrophage mediated host defense againstSalmonella typhimuriumbyMorus albaL Food Nutr Res, 2018-02-21;62(0):. 2018-02-21 [PMID: 29545736] (Mouse)
• C Burkart, A Mukhopadhy, SA Shirley, RJ Connolly, JH Wright, A Bahrami, JS Campbell, RH Pierce, DA Canton Improving therapeutic efficacy of IL-12 intratumoral gene electrotransfer through novel plasmid design and modified parameters Gene Ther., 2018-03-09;0(0):. 2018-03-09 [PMID: 29523878] (Mouse)
• M Ivin, A Dumigan, FN de Vasconc, F Ebner, M Borroni, A Kavirayani, KN Przybyszew, RJ Ingram, S Lienenklau, U Kalinke, D Stoiber, JA Bengoechea, P Kovarik Natural killer cell-intrinsic type I IFN signaling controls Klebsiella pneumoniae growth during lung infection PLoS Pathog., 2017-11-07;13(11):e1006696. 2017-11-07 [PMID: 29112952] (Mouse)
• G Dunsmore, N Bozorgmehr, C Delyea, P Koleva, A Namdar, S Elahi Erythroid Suppressor Cells Compromise Neonatal Immune Response against Bordetella pertussis J. Immunol., 2017-08-04;0(0):. 2017-08-04 [PMID: 28779022] (Mouse)
• PC Campos, MT Gomes, ES Guimarães, G Guimarães, SC Oliveira TLR7 and TLR3 Sense Brucella abortus RNA to Induce Proinflammatory Cytokine Production but They Are Dispensable for Host Control of Infection Front Immunol, 2017-01-23;8(0):28. 2017-01-23 [PMID: 28167945] (Mouse)
• Ahmed El-Hussein N-Dihydrogalactochitosan as a potent immune activator for dendritic cells J Biomed Mater Res A, 2017-01-10;0(0):. 2017-01-10 [PMID: 28028922] (Mouse)
• NLRP12 negatively regulates proinflammatory cytokine production and host defense against Brucella abortus Eur. J. Immunol., 2016-12-05;0(0):. 2016-12-05 [PMID: 27800616] (Mouse)
• Polarization of macrophages towards M2 phenotype is favored by reduction in iPLA2? J Biol Chem, 2016-09-20;0(0):. 2016-09-20 [PMID: 27650501] (Mouse)
• Poly-N-acetyl glucosamine production by Staphylococcus epidermidis cells increases their in vivo pro-inflammatory effect Infect Immun, 2016-09-19;0(0):. 2016-09-19 [PMID: 27481237] (Mouse)
• Proinflammatory M1 macrophages inhibit RANKL-induced osteoclastogenesis Infect Immun, 2016-09-19;0(0):. 2016-09-19 [PMID: 27456834] (Mouse)
• Khalid Z Matalka Eriobotrya japonica Water Extract Characterization: An Inducer of Interferon-Gamma Production Mainly by the JAK-STAT Pathway Molecules, 2016-06-02;21(6):. 2016-06-02 [PMID: 27271577] (Mouse)
• Brown A, Murphy A, Lalor S, Leech J, O'Keeffe K, Mac Aogain M, O'Halloran D, Lacey K, Tavakol M, Hearnden C, Fitzgerald-Hughes D, Humphreys H, Fennell J, van Wamel W, Foster T, Geoghegan J, Lavelle E, Rogers T, McLoughlin R Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection. PLoS Pathog, 2015-11-05;11(11):e1005226. 2015-11-05 [PMID: 26539822] (Mouse)
• Sanin D, Prendergast C, Mountford A IL-10 Production in Macrophages Is Regulated by a TLR-Driven CREB-Mediated Mechanism That Is Linked to Genes Involved in Cell Metabolism. J Immunol, 2015-06-26;195(3):1218-32. 2015-06-26 [PMID: 26116503] (Mouse)
• Pfarr K, Danciu C, Arlt O, Neske C, Dehelean C, Pfeilschifter J, Radeke H Simultaneous and dose dependent melanoma cytotoxic and immune stimulatory activity of betulin. PLoS ONE, 2015-03-10;10(3):e0118802. 2015-03-10 [PMID: 25756279] (Mouse)
• Na Y, Yoon Y, Son D, Jung D, Gu G, Seok S Consistent inhibition of cyclooxygenase drives macrophages towards the inflammatory phenotype. PLoS ONE, 2015-02-13;10(2):e0118203. 2015-02-13 [PMID: 25680189] (Mouse)
• Salama A, Fichou N, Allard M, Dubreil L, De Beaurepaire L, Viel A, Jegou D, Bosch S, Bach J MicroRNA-29b modulates innate and antigen-specific immune responses in mouse models of autoimmunity. PLoS ONE, 2014-09-09;9(9):e106153. 2014-09-09 [PMID: 25203514] (Mouse)
• Mancuso P, O Brien E, Prano J, Goel D, Aronoff D No Impairment in host defense against Streptococcus pneumoniae in obese CPEfat/fat mice. PLoS ONE, 2014-09-09;9(9):e106420. 2014-09-09 [PMID: 25203099] (Mouse)
• Petzold , Susanne, Averbeck , Marco, Simon , Jan C, Lehmann , Irina, Polte , Tobias Lifetime-dependent effects of bisphenol A on asthma development in an experimental mouse model. PLoS ONE, 2014-06-20;9(6):e100468. 2014-06-20 [PMID: 24950052] (Mouse)
• Satchidanandam V, Kumar N, Jumani R, Challu V, Elangovan S, Khan N The glycosylated Rv1860 protein of mycobacterium tuberculosis inhibits dendritic cell mediated TH1 and TH17 polarization of T cells and abrogates protective immunity conferred by BCG. PLoS Pathog, 2014-06-12;10(6):e1004176. 2014-06-12 [PMID: 24945624] (Mouse)
• Brant F, Miranda A, Esper L, Rodrigues D, Kangussu L, Bonaventura D, Soriani F, Pinho V, Souza D, Rachid M, Weiss L, Tanowitz H, Teixeira M, Teixeira A, Machado F Role of the aryl hydrocarbon receptor in the immune response profile and development of pathology during Plasmodium berghei Anka infection. Infect Immun, 2014-05-12;82(8):3127-40. 2014-05-12 [PMID: 24818665] (Mouse)
• Assi H, Espinosa J, Suprise S, Sofroniew M, Doherty R, Zamler D, Lowenstein P, Castro M Assessing the role of STAT3 in DC differentiation and autologous DC immunotherapy in mouse models of GBM. PLoS ONE, 2014-05-07;9(5):e96318. 2014-05-07 [PMID: 24806510] (Mouse)
• Badr M, Qinna N, Qadan F, Matalka K Dichloroacetate modulates cytokines toward T helper 1 function via induction of the interleukin-12-interferon-gamma pathway. Onco Targets Ther, 2014-02-07;7(0):193-201. 2014-02-07 [PMID: 24532971] (Mouse)
• Tynan , Graham A, Hearnden , Claire H, Oleszycka , Ewa, Lyons , Claire L, Coutts , Graham, O'Connell , Jean, Corrigan , Michelle, Lynch , Lydia, Campbell , Matthew, Callanan , John J, Mok , Kenneth, Geoghegan , Justin, O'Farrelly , Cliona, Allan , Stuart M, Roche , Helen M, O'Shea , Donal B, Lavelle , Ed C Endogenous oils derived from human adipocytes are potent adjuvants that promote IL-1?-dependent inflammation. Diabetes, 2014-01-23;63(6):2037-50. 2014-01-23 [PMID: 24458363] (Mouse)
• Ribes S, Meister T, Ott M, Redlich S, Janova H, Hanisch U, Nessler S, Nau R Intraperitoneal prophylaxis with CpG oligodeoxynucleotides protects neutropenic mice against intracerebral Escherichia coli K1 infection. J Neuroinflammation, 2014-01-23;11(0):14. 2014-01-23 [PMID: 24456653] (Mouse)
• Melo M, Nguyen Q, Cordeiro C, Hassan M, Yang N, McKell R, Rosowski E, Julien L, Butty V, Darde M, Ajzenberg D, Fitzgerald K, Young L, Saeij J Transcriptional analysis of murine macrophages infected with different Toxoplasma strains identifies novel regulation of host signaling pathways. PLoS Pathog, 2013-12-19;9(12):e1003779. 2013-12-19 [PMID: 24367253] (Mouse)
• Chen Y, Chen M Effects of Lactobacillus kefiranofaciens M1 isolated from kefir grains on germ-free mice. PLoS ONE, 2013-11-11;8(11):e78789. 2013-11-11 [PMID: 24244362] (Mouse)
• Selvanantham T, Escalante N, Cruz Tleugabulova M, Fieve S, Girardin S, Philpott D, Mallevaey T Nod1 and Nod2 enhance TLR-mediated invariant NKT cell activation during bacterial infection. J Immunol, 2013-10-25;191(11):5646-54. 2013-10-25 [PMID: 24163408] (Mouse)
• Koscso B, Csoka B, Kokai E, Nemeth Z, Pacher P, Virag L, Leibovich S, Hasko G Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages. J Leukoc Biol, 2013-08-06;94(6):1309-15. 2013-08-06 [PMID: 23922379] (Mouse)
• de Almeida L, Macedo G, Marinho F, Gomes M, Corsetti P, Silva A, Cassataro J, Giambartolomei G, Oliveira S Toll-like receptor 6 plays an important role in host innate resistance to Brucella abortus infection in mice. Infect Immun, 2013-03-04;81(5):1654-62. 2013-03-04 [PMID: 23460520] (Mouse)
• Schamber-Reis B, Petritus P, Caetano B, Martinez E, Okuda K, Golenbock D, Scott P, Gazzinelli R UNC93B1 and nucleic acid-sensing Toll-like receptors mediate host resistance to infection with Leishmania major. J Biol Chem, 2013-01-16;288(10):7127-36. 2013-01-16 [PMID: 23325805] (Mouse)
• Yan , L, Singh , L S, Zhang , L, Xu , Y Role of OGR1 in myeloid-derived cells in prostate cancer. Oncogene, 2012-12-10;33(2):157-64. 2012-12-10 [PMID: 23222714] (Mouse)
• Oh J, Lee R, Yu J, Ko J, Lee H, Ko A, Roddy G, Prockop D Intravenous mesenchymal stem cells prevented rejection of allogeneic corneal transplants by aborting the early inflammatory response. Mol Ther, 2012-08-28;20(11):2143-52. 2012-08-28 [PMID: 22929658] (Mouse)
• Wythe SE, Dodd JS, Openshaw PJ, Schwarze J OX40 ligand and programmed cell death 1 ligand 2 expression on inflammatory dendritic cells regulates CD4 T cell cytokine production in the lung during viral disease. J. Immunol., 2012-01-20;188(4):1647-55. 2012-01-20 [PMID: 22266281] (Mouse)
• Kang S, Okuno T, Takegahara N, Takamatsu H, Nojima S, Kimura T, Yoshida Y, Ito D, Ohmae S, You DJ, Toyofuku T, Jang MH, Kumanogoh A Intestinal epithelial cell-derived semaphorin 7A negatively regulates development of colitis via alphavbeta1 integrin. J. Immunol., 2011-12-23;188(3):1108-16. 2011-12-23 [PMID: 22198947] (Mouse)
• Veliz Rodriguez T, Moalli F, Polentarutti N, Paroni M, Bonavita E, Anselmo A, Nebuloni M, Mantero S, Jaillon S, Bragonzi A, Mantovani A, Riva F, Garlanda C Role of Toll interleukin-1 receptor (IL-1R) 8, a negative regulator of IL-1R/Toll-like receptor signaling, in resistance to acute Pseudomonas aeruginosa lung infection. Infect. Immun., 2011-10-24;80(1):100-9. 2011-10-24 [PMID: 22025515] (Mouse)
• Zhang X, Schmudde I, Laumonnier Y, Pandey MK, Clark JR, Konig P, Gerard NP, Gerard C, Wills-Karp M, Kohl J A critical role for C5L2 in the pathogenesis of experimental allergic asthma. J. Immunol., 2010-10-25;185(11):6741-52. 2010-10-25 [PMID: 20974988] (Mouse)
• Sellge G, Magalhaes JG, Konradt C, Fritz JH, Salgado-Pabon W, Eberl G, Bandeira A, Di Santo JP, Sansonetti PJ, Phalipon A Th17 cells are the dominant T cell subtype primed by Shigella flexneri mediating protective immunity. J. Immunol., 2010-01-20;184(4):2076-85. 2010-01-20 [PMID: 20089698] (Mouse)
• Molle C, Goldman M, Goriely S Critical role of the IFN-stimulated gene factor 3 complex in TLR-mediated IL-27p28 gene expression revealing a two-step activation process. J. Immunol., 2010-01-18;184(4):1784-92. 2010-01-18 [PMID: 20083668] (Mouse)
• Reynolds CM, Draper E, Keogh B, Rahman A, Moloney AP, Mills KH, Loscher CE, Roche HM A conjugated linoleic acid-enriched beef diet attenuates lipopolysaccharide-induced inflammation in mice in part through PPARgamma-mediated suppression of toll-like receptor 4. J. Nutr., 2009-10-21;139(12):2351-7. 2009-10-21 [PMID: 19846417] (Mouse)
• Aronoff DM, Lewis C, Serezani CH, Eaton KA, Goel D, Phipps JC, Peters-Golden M, Mancuso P E-prostanoid 3 receptor deletion improves pulmonary host defense and protects mice from death in severe Streptococcus pneumoniae infection. J. Immunol., 2009-07-27;183(4):2642-9. 2009-07-27 [PMID: 19635910] (Mouse)
• Steinberg C, Eisenacher K, Gross O, Reindl W, Schmitz F, Ruland J, Krug A The IFN regulatory factor 7-dependent type I IFN response is not essential for early resistance against murine cytomegalovirus infection. Eur. J. Immunol., 2009-04-01;39(4):1007-18. 2009-04-01 [PMID: 19283778] (Mouse)
• Wong KL, Lew FC, MacAry PA, Kemeny DM CD40L-expressing CD8 T cells prime CD8alpha(+) DC for IL-12p70 production. Eur. J. Immunol., 2008-08-01;38(8):2251-62. 2008-08-01 [PMID: 18600823] (Mouse)
• Liu J, Dolan MC, Reidy M, Cramer CL Expression of bioactive single-chain murine IL-12 in transgenic plants. J. Interferon Cytokine Res., 2008-06-01;28(0):381-92. 2008-06-01 [PMID: 18593333] (Mouse)
• Wan S, Zhou Z, Duan B, Morel L Direct B cell stimulation by dendritic cells in a mouse model of lupus. Arthritis Rheum., 2008-06-01;8(0):1741-50. 2008-06-01 [PMID: 18512810] (Mouse)
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FAQs for IL-12 p70/IL-12A (DY419). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: Il12a